Nomenclature

Gene Symbol
SNRPD2 (H. sapiens)
Other Gene Symbols
SMD2, SNRPD1, Sm-D2
Full Name
small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
Other Names
SmD2, small nuclear ribonucleoprotein Sm D2, snRNP core protein D2

Other Resources

Entrez: Gene Info
6633
Uniprot: Protein Info
SMD2_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112517
PDB: Structures
1B34, 2Y9A, 2Y9B, 2Y9C, 2Y9D
SpliProt3D: Structural Model
SNRPD2

Gene Product Info

Molecular Weight (kD)
13.5
Domains
—
Motifs
—
Features
—
Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex, tri-snRNP, U1 snRNP, U4/U6 snRNP, U5 snRNP
Class / Family
Sm
Notes
—

Orthologs

Name Organism
SMD2 S. cerevisiae
smd2 S. pombe
SmD2 D. melanogaster
C52E4.3 C. elegans

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SNRPD2 SNRPD1 Dervied from Literature — 9417867, 10025403, 12975319
SNRPD2 SNRPD2 Dervied from Literature — 11756452
SNRPD2 SNRPE Dervied from Literature — 9417867
SNRPD2 SNRPF Dervied from Literature — 9417867, 11226169
SNRPD2 SNRPF Y2H: Bidirectional 1 22365833
SNRPD2 LSM2 Dervied from Literature — 14667819, 15231747
SNRPD2 LSM2 Y2H: Bidirectional 1 22365833
SNRPD2 LSM4 Dervied from Literature — 11920408
SNRPD2 LSM6 Y2H: Bait/Prey 1 22365833
SNRPD2 LSM6 Dervied from Literature — 15231747
SNRPD2 ZCCHC10 Y2H: Prey/Bait 1 22365833
SNRPD2 SMN1 Dervied from Literature — 9323129, 10556282, 10942426

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 356 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 325 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 279 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 253 21536652
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 205 21536652
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 195 21386897
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 156 21386897
U1 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 129 21536652
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 103 16809785
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 98 21536652
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 74 20980672
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 72 27377154
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 68 18322460
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 60 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 59 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 59 24448447
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 52 20980672
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 51 27377154
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 48 20980672
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 46 16809785
Saf3 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 44 21386897
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 42 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 39 27377154
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 34 20980672
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 32 16809785
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 32 19935684
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 30 18322460
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 30 19935684
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 27 18322460
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 27 19941820
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 27 24448447
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 26 17332742
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 26 19941820
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 26 27377154
Urn1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 25 21386897
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 24 18322460
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 22 27377154
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 21 21386897
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 21 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 21 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 21 19935684
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 21 23431055
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 20 24448447
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 19 18981222
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 19 19935684
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 18 18981222
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 18 19935684
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 17 18322460
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 17 18981222
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 17 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 16 18981222
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 16 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 16 19935684
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 15 19761775
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 14 18981222
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 14 19935684
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 14 23431055
Prp8 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 13 19789211
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 13 23431055
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 13 23431055
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 12 17537823
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 12 23431055
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 11 22110043
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 10 19941820
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 10 18193060
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 10 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 10 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 10 16809785
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 9 18193060
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 9 19941820
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 9 18193060
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 9 18193060
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 9 22110043
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
Saf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 8 21386897
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 8 23431055
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 7 19941820
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 7 12509417
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 7 19789211
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 7 23431055
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 6 19941820
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 6 12226669
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 6 23431055
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 5 11804584
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 5 12226669
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 5 11884590
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 5 17537823
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 5 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 5 23345524
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 4 23431055
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 3 19761775
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 3 11991638
Aim4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 3 21386897
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 3 21526149
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
tri-snRNP, S. cerevisiae, (Stevens et al 1999) S. cerevisiae ■ 11720284
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
tri-snRNP, S. cerevisiae, (Gottschalk et al 1999) S. cerevisiae ■ 10449419
A-like complex (A') Weri, H. sapiens, (Sharma et al 2008) H. sapiens ■ 18193060
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
U1 snRNP, S. pombe, (Newo et al 2007) S. pombe ■ 17264129
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, without splicing substrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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