Nomenclature

Gene Symbol
SNRPE (H. sapiens)
Other Gene Symbols
B-raf, SME, Sm-E
Full Name
small nuclear ribonucleoprotein polypeptide E
Other Names
SmE1, sm protein E, small nuclear ribonucleoprotein E, snRNP-E

Other Resources

Entrez: Gene Info
6635
Uniprot: Protein Info
RUXE_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112519
PDB: Structures
2Y9A, 2Y9B, 2Y9C, 2Y9D, 3CW1
SpliProt3D: Structural Model
SNRPE

Gene Product Info

Molecular Weight (kD)
10.8
Domains
—
Motifs
—
Features
—
Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex, tri-snRNP, U1 snRNP, U4/U6 snRNP, U5 snRNP
Class / Family
Sm
Notes
—

Orthologs

Name Organism
SME1 S. cerevisiae
sme1 S. pombe
SmE D. melanogaster
Y49E10.15 C. elegans
MAL13P1.253 P. falciparum
SNRPE G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SNRPE SNRPD2 Dervied from Literature — 9417867
SNRPE SNRPD3 Dervied from Literature — 9417867
SNRPE SNRPE Dervied from Literature — 9417867
SNRPE SNRPF Dervied from Literature — 9417867, 11226169
SNRPE SNRPF Y2H: Bidirectional 1 22365833
SNRPE SNRPG Dervied from Literature — 9417867, 11226169
SNRPE LSM2 Dervied from Literature — 14667819, 15231747
SNRPE LSM3 Dervied from Literature — 15231747
SNRPE LSM4 Dervied from Literature — 15231747
SNRPE LSM5 Dervied from Literature — 15231747
SNRPE SMN1 Dervied from Literature — 9323129, 10556282

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 434 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 336 21536652
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 295 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 257 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 213 21536652
U1 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 201 21536652
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 162 21386897
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 147 21536652
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 101 21386897
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 70 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 65 27377154
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 45 16809785
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 39 21386897
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 31 27377154
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 28 16809785
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 25 18322460
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 25 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 24 18322460
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 23 18322460
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 22 16809785
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 22 24448447
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 21 24448447
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 18 20980672
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 18 24448447
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 18 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 17 27377154
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 14 20980672
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 14 19935684
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 12 20980672
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 10 18322460
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 10 24448447
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 9 17332742
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 9 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 8 19761775
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 7 19941820
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 7 19935684
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 7 23431055
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 6 19941820
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 6 20980672
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 6 19935684
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 5 19941820
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 5 17537823
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 5 18981222
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 5 19935684
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 4 18322460
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 4 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 4 19935684
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 4 23431055
CACN-1 pulldown with FLAG-HA tandem affinity from C. elegans, C. elegans, (Doherty et al 2014) C. elegans 4 24948787
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 3 19761775
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 3 23345524
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 2 11991638
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 2 17537823
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 2 23345524
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 1 11804584
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 1 16809785
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 1 12509417
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 1 21526149
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
tri-snRNP, S. cerevisiae, (Gottschalk et al 1999) S. cerevisiae ■ 10449419
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
A-like complex (A') Weri, H. sapiens, (Sharma et al 2008) H. sapiens ■ 18193060
tri-snRNP, S. cerevisiae, (Stevens et al 1999) S. cerevisiae ■ 11720284
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
U1 snRNP, S. pombe, (Newo et al 2007) S. pombe ■ 17264129
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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