Nomenclature

Gene Symbol
SNRPD3 (H. sapiens)
Other Gene Symbols
SMD3, Sm-D3
Full Name
small nuclear ribonucleoprotein D3 polypeptide 18kDa
Other Names
SmD3, small nuclear ribonucleoprotein Sm D3, small nuclear ribonucleoprotein polypeptide D3, snRNP core protein D3

Other Resources

Entrez: Gene Info
6634
Uniprot: Protein Info
SMD3_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112518
PDB: Structures
1D3B, 2Y9A, 2Y9B, 2Y9C, 2Y9D
SpliProt3D: Structural Model
SNRPD3

Gene Product Info

Molecular Weight (kD)
13.9
Domains
—
Motifs
—
Features
—
Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex, tri-snRNP, U1 snRNP, U4/U6 snRNP, U5 snRNP
Class / Family
Sm
Notes
—

Orthologs

Name Organism
SMD3 S. cerevisiae
smd3 S. pombe
SmD3 D. melanogaster
Y116A8C.42 C. elegans
SNRPD3 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SNRPD3 SNRPB Y2H: Bait/Prey 1 22365833
SNRPD3 SNRPB Dervied from Literature — 10025403, 10322216, 10601333, 10725331, 10851237, 11748230, 11756452
SNRPD3 SNRPD3 Dervied from Literature — 11756452
SNRPD3 SNRPE Dervied from Literature — 9417867
SNRPD3 SNRPG Dervied from Literature — 9417867
SNRPD3 LSM3 Dervied from Literature — 15231747
SNRPD3 LSM3 Y2H: Bidirectional 1 22365833
SNRPD3 LSM7 Y2H: Bait/Prey 1 22365833
SNRPD3 LSM7 Dervied from Literature — 15231747
SNRPD3 SNRPC Dervied from Literature — 19325628
SNRPD3 DHX9 Dervied from Literature — 11149922
SNRPD3 PRMT5 Dervied from Literature — 11713266, 11720283
SNRPD3 SMN1 Dervied from Literature — 9323129, 10556282, 10851237, 11720283

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 284 21386897
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 259 21386897
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 134 21386897
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 65 16809785
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 59 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 57 27377154
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 46 18322460
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 45 16809785
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 45 27377154
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 44 24448447
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 40 19935684
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 38 20980672
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 36 27377154
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 35 20980672
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 35 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 35 24448447
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 34 27377154
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 26 18322460
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 26 19935684
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 25 19935684
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 25 27377154
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 23 16809785
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 22 18322460
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 21 17332742
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 21 19935684
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 19 18322460
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 19 23431055
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 18 18981222
Prp8 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 18 19789211
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 18 23431055
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 17 20980672
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 17 18981222
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 15 18981222
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 15 20980672
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 15 18981222
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 15 19935684
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 15 24448447
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 15 24448447
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 14 19941820
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 14 19935684
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 13 21386897
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 12 19935684
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 12 23431055
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 11 19935684
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 11 23431055
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 10 19941820
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 10 18193060
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 10 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 10 19935684
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 9 18322460
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 9 18981222
Saf3 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 9 21386897
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 9 23431055
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 9 23431055
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 8 19941820
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 8 23431055
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 7 19761775
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 6 19941820
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 6 18193060
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 5 11804584
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 5 17537823
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 5 16809785
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 5 19789211
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 5 23345524
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 5 22110043
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 4 19941820
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 4 17537823
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 4 11884590
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 4 23345524
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 3 19941820
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 3 12509417
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 3 21526149
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 2 21526149
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
H complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
tri-snRNP, S. cerevisiae, (Stevens et al 1999) S. cerevisiae ■ 11720284
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
tri-snRNP, S. cerevisiae, (Gottschalk et al 1999) S. cerevisiae ■ 10449419
EDC complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
A-like complex (A') Weri, H. sapiens, (Sharma et al 2008) H. sapiens ■ 18193060
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
U1 snRNP, S. pombe, (Newo et al 2007) S. pombe ■ 17264129
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
U1 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens ■ 21536652
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens ■ 21536652
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens ■ 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens ■ 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens ■ 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens ■ 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens ■ 21536652

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