Links to Cryo-EM structures of spliceosomes

(updated Dec 2022)

Primary EMD- entryComplexOrganismLabResolutionPDB modelRelated EMD- Maps
EMD-6915SF3B complex with E7107HumanLarsen4.0 Å5zya
EMD-31330SF3B complex with DDX42HumanShi2.6 Å7evn
EMD-8622U1snRNPS. cerevisiaeZhao3.7Å5uz5
EMD-1068817S U2 snRNPHumanLührmann/Stark7.1 Å6Y5Q10689
EMD-1068917S U2 snRNP 5' domainHumanLührmann/Stark4.1 Å6Y5010688
EMD-1068817S U2 snRNP lower resolution regionHumanLührmann/Stark7.1 Å6Y5310689
EMD-3133417S U2 snRNPHumanShi2.5 Å7evo
EMD-1379317S U2 snRNP 5' domainHumanGalej2.2 Å7q3l
EMD-13812U2 snRNP after ATP remodelingHumanGalej2.2 Å7q4p
EMD-1847U5 35S complexHumanLührmann/Stark27.8Åna1847
EMD-2966tri-snRNPS. cerevisiaeNagai5.9Åna2966
EMD-8012tri-snRNPS. cerevisiaeNagai3.7Å5gan8006, 8007, 8008, 8009, 8010, 8012, 8011, 8013, 8014
EMD-6561tri-snRNPS. cerevisiaeShi3.81Å3jcm6561, 6562, 6563, 6564, 6565, 6566, 6567, 6568, 6569, 6570, 6571, 6572, 6573
EMD-8014tri-snRNP, body regionS. cerevisiaeNagai3.6Å5gap8006, 8007, 8008, 8009, 8010, 8012, 8011, 8013, 8014
EMD-8011tri-snRNP, foot regionS. cerevisiaeNagai3.7Å5gam8006, 8007, 8008, 8009, 8010, 8012, 8011, 8013, 8014
EMD-8013tri-snRNP, head regionS. cerevisiaeNagai4.2Å5gao8006, 8007, 8008, 8009, 8010, 8012, 8011, 8013, 8014
EMD-0360E complex on UBC4 intronS. cerevisiaeZhao3.6Å6n7p
EMD-0361E complex on ACT1 intronS. cerevisiaeZhao3.2Å6n7r
EMD-13033pre-A complexS. cerevisiaeLührmann/Stark5.9 Å7oqe13030, 13031, 13032
EMD-13028pre-A complex U2 snRNP portionS. cerevisiaeLührmann/Stark9 Å7oqb13030, 13031, 13032
EMD-13029pre-A complex U1 snRNP portionS. cerevisiaeLührmann/Stark4.1 Å7oqc13030, 13031, 13032
EMD-12994SSA-bound A complex U2 snRNP 5' moduleHumanPena3.1 Å7onb
EMD-13811A-like U2 snRNP bound to BP oligoHumanGalej2.1 Å7q4o
EMD-4364A complexS. cerevisiaeNagai4.0 Å6g904363, 4365,
EMD-3682Pre-B complexS. cerevisiaeNagai3.9 Å5nrl3682, 3683, 3684, 3685, 3686, 3687, 3688
EMD-4665Pre-B complexHumanNagai3.3 Å6qx9
EMD-9621Pre-B complexHumanShi5.7 Å6ah0
EMD-6973Pre-B complex: U1 snRNP region)S. cerevisiaeShi3.4 Å5zwm
EMD-6974B complexS. cerevisiaeShi3.9 Å5zwo
EMD-9624B complexHumanShi3.8 Å6ahd
EMD-1066B complexHumanLührmann/Stark40 Åna1066
EMD-3766B complexHumanLührmann/Stark4.5 Å5o9z3766, 3767, 3768, 3769
EMD-11694pre-Bact-1 coreHumanLührmann/Stark3.9 Å7abf11693, 11695, 11696
EMD-11695pre-Bact-1HumanLührmann/Stark7.8 Å7abg11693, 11694, 11696
EMD-11693pre-Bact-2 coreHumanLührmann/Stark4.2 Å7aav11694, 11695, 11696
EMD-11696pre-Bact-2 (SF3b/U2 snRNP portion)HumanLührmann/Stark4.5 Å7abh11693, 11694, 11695
EMD-11697pre-Bact-2HumanLührmann/Stark8.0 Å7abi
EMD-9524Bact complexS. cerevisiaeShi3.5 Å5gm6
EMD-4099Bact complexS. cerevisiaeLührmann/Stark5.8 Å5lqw4099
EMD-4254Bact complexHumanLührmann/Stark3.7 Åna4233-4240, 4247-4252
EMD-4240Bact coreHumanLührmann/Stark4.5 Å6ff7
EMD-4255Bact coreHumanLührmann/Stark3.4 Å6ff4
EMD-6891Bact-1 complexHumanShi4.9 Å5z58
EMD-6889Bact-2 complexHumanShi5.1 Å5z56
EMD-6890Bact-3 complexHumanShi6.5 Å5z57
EMD-30637Bact complexS. cerevisiaeShi2.5 Å7dco12107-12117
EMD-30875Bact complex Minor spliceosomeHumanShi2.9 Å7dvq30875, 30879
EMD-0687B*-a1 complexS. cerevisiaeShi3.6 Å6j6h0684,0685,0686,0691,0692
EMD-0686B*-a2 complexS. cerevisiaeShi3.2 Å6j6g0684,0685,0687,0691,0692
EMD-0691B*-b1 complexS. cerevisiaeShi3.9 Å6j6n0684,0685,0686,0687,0692
EMD-0692B*-a2 complexS. cerevisiaeShi3.7 Å6j6q0684,0685,0686,0691,0687
EMD-12106C complex with Prp18/Slu7S. cerevisiaeNagai2.8 Å7b9v12107-12117
EMD-4055C complexS. cerevisiaeNagai3.8 Å5lj34055, 4056, 4057, 4058, 4059
EMD-4057C complexS. cerevisiaeNagai10 Å5lj54055, 4056, 4057, 4058, 4059
EMD-9525C complexS. cerevisiaeShi3.4 Å5gmk9525, 9526, 9527
EMD-11569C complex coreHumanLührmann/Stark3.4 Å6zym11570
EMD-11570C complex peripheryHumanLührmann/Stark5 Å7a5p11569
EMD-6864C complexHumanShi4.1 Å5yzg
EMD-1846C complexHumanLührmann/Stark29 Åna1846
EMD-1062C complexHumanMoore/Grigorieff30 Åna1062
EMD-1848C complex, high salt coreHumanLührmann/Starknana1848
EMD-32317pre-C*-I complexHumanShi3.6 Å7w59
EMD-32319pre-C*-II complexHumanShi3.6 Å7w5a
EMD-32321C* complexHumanShi4.3 Å7w5b
EMD-3539C* complexS. cerevisiaeNagai3.9 Å5mps3539, 3541, 3542
EMD-3541C* complexS. cerevisiaeNagai4.2 Å5mq03539, 3541, 3542
EMD-6684C* complexS. cerevisiaeShi4 Å5wsg6684
EMD-3545C* complexHumanLührmann/Stark5.9 Å5mqf3545, 3547
EMD-6721C* complexHumanShi3.6Å5xjc6721
EMD-7109P complexS. cerevisiaeZhao3.3 Å6bk8
EMD-3979P w/ 3' SS dockedS. cerevisiaeNagai3.7 Å6exn3980
EMD-3980P w/ 3' SS undockedS. cerevisiaeNagai4 ÅNone3979
EMD-6839P complexS. cerevisiaeShi3.6 Å5ylz
EMD-4525P complexHumanNagai3.3 Å6qdv
EMD-9645P complexHumanShi3.0 Å6icz
EMD-6413Released intron complexS. pombeShi3.6 Å3jb96413, 6414, 6415, 6416, 6417, 6418, 6419, 6420, 6421
EMD-6817Released intron complexS. cerevisiaeShi3.5 Å5y88
EMD-9646Released intron complexHumanShi2.9 Å6id0
EMD-9647Released intron complex w/ Prp43HumanShi2.9 Å6id1
EMD-1294SupraspliceosomeHumanSperling22 Åna1294

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