Nomenclature

Gene Symbol
SNW1 (H. sapiens)
Other Gene Symbols
Bx42, MGC119379, NCOA-62, PRPF45, Prp45
Full Name
SNW domain containing 1
Other Names
SKIP, SKI interacting protein, SKI-interacting protein, SNW domain-containing protein 1, homolog of Drosophila BX42, nuclear protein SkiP

Other Resources

Entrez: Gene Info
22938
Uniprot: Protein Info
SNW1_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
116597
PDB: Structures
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SpliProt3D: Structural Model
SNW1

Gene Product Info

Molecular Weight (kD)
61.5
Domains
—
Motifs
—
Features
—
Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 related
Notes
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Orthologs

Name Organism
PRP45 S. cerevisiae
prp45 S. pombe
Bx42 D. melanogaster
T27F2.1 C. elegans
SNW1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SNW1 NHP2L1 Y2H: Prey/Bait 0.33 22365833
SNW1 SART1 Pull-down — 22365833
SNW1 SART1 Y2H: Prey/Bait 0.5 22365833
SNW1 CTNNBL1 Pull-down — 22365833
SNW1 CTNNBL1 Y2H: Prey/Bait 0.5 22365833
SNW1 XAB2 Pull-down — 22365833
SNW1 XAB2 Y2H: Prey/Bait 0.5 22365833
SNW1 PPIL1 Dervied from Literature — 16595688
SNW1 MFAP1 Y2H: Prey/Bait 0.5 22365833
SNW1 ZNF830 Y2H: Prey/Bait 0.5 22365833
SNW1 ZNF830 Pull-down — 22365833
SNW1 CXorf56 Y2H: Prey/Bait 0.33 22365833
SNW1 SNIP1 Y2H: Prey/Bait 0.5 22365833
SNW1 SNIP1 Pull-down — 22365833
SNW1 TTC14 Y2H: Prey/Bait 0.75 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 538 21386897
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 425 21386897
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 383 21386897
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 275 20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 229 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 195 20980672
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 163 21536652
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 132 20980672
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 130 21536652
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 113 19935684
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 89 23431055
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 82 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 79 24448447
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 70 19941820
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 69 27377154
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 68 24448447
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 67 19935684
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 66 18322460
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 65 19935684
Urn1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 64 21386897
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 60 18322460
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 59 19935684
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 58 24448447
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 55 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 51 19935684
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 51 19935684
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 50 21536652
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 49 18322460
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 49 19935684
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 46 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 44 19935684
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 41 16809785
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 40 18981222
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 37 19941820
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 37 18322460
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 37 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 35 27377154
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 34 23345524
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 31 23345524
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 30 16809785
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 29 23431055
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 28 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 28 16809785
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 28 23431055
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 28 23431055
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 27 24448447
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 26 16809785
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 26 23431055
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 22 23431055
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 21 20089683
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 21 23431055
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 20 19761775
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 20 23431055
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 19 19941820
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 19 18981222
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 19 23431055
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 18 11884590
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 18 11884590
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 18 11804584
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 18 11991638
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 16 17537823
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 16 11884590
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 15 19941820
Aim4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 15 21386897
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 15 23431055
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 15 23431055
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 13 11884590
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 13 19941820
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 13 11884590
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 13 18981222
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 12 11884590
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 12 18981222
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 11 21386897
CACN-1 pulldown with FLAG-HA tandem affinity from C. elegans, C. elegans, (Doherty et al 2014) C. elegans 11 24948787
Saf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 9 21386897
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 8 19761775
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 8 12226669
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 7 21526149
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 7 27377154
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 6 12226669
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 5 19941820
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 5 20089683
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 4 20089683
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 4 12509417
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 4 19789211
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
SRM160 pulldown with BIC8 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 3 16159877
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 2 11991638
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 2 17537823
Prp8 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 2 19789211
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 2 21526149
SRM160 pulldown with Srm160 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 2 16159877
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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