Nomenclature

Gene Symbol
XAB2 (H. sapiens)
Other Gene Symbols
DKFZp762C1015, HCNP, HCRN, NTC90, SYF1
Full Name
XPA binding protein 2
Other Names
XAB2, SYF1 homolog, RNA splicing factor, XPA-binding protein 2, crn-related protein kim1, pre-mRNA-splicing factor SYF1

Other Resources

Entrez: Gene Info
56949
Uniprot: Protein Info
SYF1_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
121273
PDB: Structures
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SpliProt3D: Structural Model
XAB2

Gene Product Info

Molecular Weight (kD)
100.0
Domains
—
Motifs
—
Features
—
Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 related
Notes
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Orthologs

Name Organism
SYF1 S. cerevisiae
cwf3 S. pombe
CG6197 D. melanogaster
C50F2.3 C. elegans

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
XAB2 SF3B2 Y2H: Bait/Prey 0.5 22365833
XAB2 SF3B2 Pull-down — 22365833
XAB2 PPIE Dervied from Literature — 16189514
XAB2 PPIE Y2H: Prey/Bait 1 22365833
XAB2 PPIE Pull-down — 22365833
XAB2 SNW1 Y2H: Bait/Prey 0.5 22365833
XAB2 SNW1 Pull-down — 22365833
XAB2 ISY1 Y2H: Prey/Bait 1 22365833
XAB2 ISY1 Pull-down — 22365833
XAB2 IK Pull-down — 22365833
XAB2 IK Y2H: Bidirectional 1 22365833
XAB2 DHX16 Y2H: Bait/Prey 1 22365833
XAB2 DHX16 Pull-down — 22365833
XAB2 ILF3 Y2H: Bait/Prey 0.5 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 1046 21386897
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 992 21386897
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 939 21386897
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 318 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 288 20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 214 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 211 20980672
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 166 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 162 19935684
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 153 23431055
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 151 18322460
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 151 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 151 27377154
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 143 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 143 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 133 19935684
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 131 21536652
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 124 19941820
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 124 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 120 19935684
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 120 19935684
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 111 23431055
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 104 19935684
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 98 18322460
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 97 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 91 24448447
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 87 23431055
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 81 23431055
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 77 18322460
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 76 23431055
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 70 23431055
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 69 19941820
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 67 19941820
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 64 19935684
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 59 23431055
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 56 23345524
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 54 23345524
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 53 18322460
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 53 18322460
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 53 24448447
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 52 19941820
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 52 23431055
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 51 23431055
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 47 27377154
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 45 16809785
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 39 18981222
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 39 23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 38 23431055
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 36 20089683
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 36 18322460
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 36 18981222
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 36 27377154
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 34 11884590
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 31 24448447
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 28 19941820
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 28 11991638
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 28 21536652
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 24 11884590
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 22 12509417
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 19 19941820
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 18 11884590
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 18 11884590
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 16 20089683
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 15 17537823
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 15 16809785
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 15 23431055
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 13 20089683
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 13 17537823
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 13 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 13 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 13 18981222
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 13 21526149
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 12 12226669
CACN-1 pulldown with FLAG-HA tandem affinity from C. elegans, C. elegans, (Doherty et al 2014) C. elegans 12 24948787
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 11 11884590
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
Saf1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 10 21386897
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 8 11804584
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 8 12226669
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 5 16809785
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 4 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 2 16809785
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 2 21526149
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 1 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 1 27377154
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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