Nomenclature

Gene Symbol
PPIE (H. sapiens)
Other Gene Symbols
CYP-33, CYP33, MGC111222, MGC3736
Full Name
peptidylprolyl isomerase E (cyclophilin E)
Other Names
Cyclophilin E, PPIase E, cyclophilin-33, peptidyl-prolyl cis-trans isomerase E, rotamase E

Other Resources

Entrez: Gene Info
10450
Uniprot: Protein Info
PPIE_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
115714
PDB: Structures
1ZMF, 2CQB, 2KU7, 2KYX, 2R99
SpliProt3D: Structural Model
PPIE

Gene Product Info

Molecular Weight (kD)
33.4
Domains
PPIase cyclophilin-type, RRM
Motifs
—
Features
—
Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 related
Notes
—

Orthologs

Name Organism
PPIL4 H. sapiens
rct1 S. pombe
cyp33 D. melanogaster
CG5808 D. melanogaster
F39H2.2 C. elegans
Y116A8C.34 C. elegans
PPIE G. gallus
PPIL4 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PPIE XAB2 Y2H: Bait/Prey 1 22365833
PPIE XAB2 Pull-down — 22365833
PPIE XAB2 Dervied from Literature — 16189514

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 220 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 201 21536652
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 68 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 53 20980672
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 53 21536652
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 47 20980672
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 42 27377154
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 30 20980672
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 23 24448447
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 21 18981222
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 20 18322460
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 20 18981222
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 18 11991638
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 18 27377154
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 16 19761775
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 15 18322460
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 13 18322460
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 13 18322460
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 13 18322460
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 12 23345524
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 11 16809785
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 11 24448447
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 10 23345524
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 10 24448447
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 6 24448447
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 5 27377154
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 4 17537823
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 3 19761775
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 3 16809785
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 3 16809785
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 3 16809785
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 3 27377154
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 2 18981222
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 1 16809785
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 1 21526149
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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