Nomenclature

Gene Symbol
DHX16 (H. sapiens)
Other Gene Symbols
DBP2, DDX16, PRO2014, PRP8, PRPF2
Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 16
Other Names
DDX16, ATP-dependent RNA helicase #3, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16, DEAD/H box 16, DEAH-box protein 16, RNA helicase

Other Resources

Entrez: Gene Info
8449
Uniprot: Protein Info
DHX16_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
114027
PDB: Structures
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SpliProt3D: Structural Model
DHX16

Gene Product Info

Molecular Weight (kD)
119.3
Domains
Helicase ATP-binding, Helicase C-terminal
Motifs
DEAH box
Features
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Complex Association
Bact complex, C complex, P complex
Class / Family
Recruited at Bact complex
Notes
—

Orthologs

Name Organism
PRP2 S. cerevisiae
cdc28 S. pombe
l(2)37Cb D. melanogaster
C04H5.6 C. elegans

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
DHX16 SF3B2 Y2H: Bait/Prey 0.62 22365833
DHX16 SF3B2 Pull-down — 22365833
DHX16 XAB2 Pull-down — 22365833
DHX16 XAB2 Y2H: Prey/Bait 1 22365833
DHX16 GPKOW Pull-down — 22365833
DHX16 GPKOW Y2H: Bidirectional 1 22365833
DHX16 DHX38 Pull-down — 22365833
DHX16 DHX38 Y2H: Bidirectional 1 22365833
DHX16 DGCR14 Y2H: Bait/Prey 0.67 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 157 20980672
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 136 20980672
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 136 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 136 19935684
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 116 19941820
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 107 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 94 19935684
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 81 18322460
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 81 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 78 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 77 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 73 19935684
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 65 20980672
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 64 19941820
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 59 20089683
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 56 20980672
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 51 21536652
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 38 18322460
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 35 18322460
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 33 21536652
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 33 24448447
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 27 18322460
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 24 19941820
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 20 24448447
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 19 19941820
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 17 24448447
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 14 24448447
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 13 23345524
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 12 18322460
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 10 21536652
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 6 12226669
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 6 23345524
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 5 12226669
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 4 19761775
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 3 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 3 16809785
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 2 19761775
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 2 19935684
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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