Nomenclature

Gene Symbol
IK (H. sapiens)
Other Gene Symbols
CSA2, MGC59741, RED
Full Name
IK cytokine, down-regulator of HLA II
Other Names
RED protein, IK factor, RD element, chondrosarcoma-associated protein 2, cytokine IK, prer protein

Other Resources

Entrez: Gene Info
3550
Uniprot: Protein Info
RED_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
109766
PDB: Structures
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SpliProt3D: Structural Model
IK

Gene Product Info

Molecular Weight (kD)
65.6
Domains
—
Motifs
—
Features
—
Complex Association
B complex
Class / Family
Recruited at B complex
Notes
—

Orthologs

Name Organism
CG18005 D. melanogaster
Y49F6B.4 C. elegans
IK G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
IK EFTUD2 Pull-down — 22365833
IK EFTUD2 Y2H: Bidirectional 0.74 22365833
IK PRPF6 Pull-down — 22365833
IK PRPF6 Y2H: Bidirectional 0.98 22365833
IK CTNNBL1 Y2H: Bidirectional 1 22365833
IK XAB2 Pull-down — 22365833
IK XAB2 Y2H: Bidirectional 1 22365833
IK SMU1 Pull-down — 22365833
IK SMU1 Y2H: Bidirectional 0.98 22365833
IK MFAP1 Pull-down — 22365833
IK MFAP1 Y2H: Bidirectional 1 22365833
IK IK Y2H: Homodimer 0.81 22365833
IK IK Pull-down — 22365833
IK IK Pull-down — 22365833
IK ZNF830 Y2H: Prey/Bait 1 22365833
IK ZNF830 Pull-down — 22365833
IK RNF113A Y2H: Prey/Bait 1 22365833
IK RNF113A Pull-down — 22365833
IK SNIP1 Y2H: Bait/Prey 0.8 22365833
IK SNIP1 Pull-down — 22365833
IK GNB2L1 Y2H: Bidirectional 0.74 22365833
IK THOC1 Y2H: Prey/Bait 0.94 22365833
IK RBM10 Pull-down — 22365833
IK RBM10 Y2H: Prey/Bait 1 22365833
IK TTC14 Y2H: Prey/Bait 0.75 22365833
IK ZCCHC10 Y2H: Prey/Bait 1 22365833
IK FRA10AC1 Pull-down — 22365833
IK TOE1 Y2H: Bidirectional 0.78 22365833
IK FRA10AC1 Y2H: Bidirectional 0.95 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 152 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 68 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 60 21536652
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 58 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 54 24448447
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 43 18322460
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 42 27377154
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 38 16809785
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 35 16809785
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 34 27377154
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 32 24448447
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 31 16809785
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 30 16809785
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 29 20980672
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 17 18981222
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 15 20980672
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 15 27377154
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 14 20980672
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 10 20980672
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 10 18981222
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 9 21536652
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 8 18981222
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 7 17537823
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 7 17537823
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 6 23345524
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 5 24448447
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 4 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 4 21536652
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 4 23345524
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 3 24448447
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 2 11991638
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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