Nomenclature

Gene Symbol
PRPF6 (H. sapiens)
Other Gene Symbols
ANT-1, ANT1, C20orf14, Prp6, TOM
Full Name
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
Other Names
U5-102kD, PRP6 homolog, U5 snRNP-associated 102 kDa protein, U5-102 kDa protein, androgen receptor N-terminal domain transactivating protein-1, androgen receptor N-terminal domain-transactivating protein 1

Other Resources

Entrez: Gene Info
24148
Uniprot: Protein Info
PRP6_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
117298
PDB: Structures
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SpliProt3D: Structural Model
PRPF6

Gene Product Info

Molecular Weight (kD)
106.9
Domains
—
Motifs
—
Features
—
Complex Association
B complex, tri-snRNP, U5 snRNP
Class / Family
U5 snRNP
Notes
—

Orthologs

Name Organism
PRP6 S. cerevisiae
prp1 S. pombe
CG6841 D. melanogaster
Y59A8B.6 C. elegans
PRPF6 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PRPF6 SNRNP200 Dervied from Literature — 16723661
PRPF6 PRPF8 Dervied from Literature — 16723661
PRPF6 PRPF6 Dervied from Literature — 10848612, 16723661
PRPF6 CD2BP2 Y2H: Bait/Prey 0.5 22365833
PRPF6 CD2BP2 Dervied from Literature — 15840814
PRPF6 CD2BP2 Pull-down — 22365833
PRPF6 TXNL4A Dervied from Literature — 16723661
PRPF6 PRPF31 Dervied from Literature — 16723661, 17412961
PRPF6 PRPF31 Y2H: Prey/Bait 0.66 22365833
PRPF6 PRPF31 Pull-down — 22365833
PRPF6 SART1 Dervied from Literature — 16723661
PRPF6 IK Pull-down — 22365833
PRPF6 IK Y2H: Bidirectional 0.98 22365833
PRPF6 SRRM2 Y2H: Prey/Bait 0.68 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 441 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 301 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 170 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 159 24448447
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 153 21536652
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 141 27377154
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 109 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 108 21536652
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 105 27377154
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 99 16809785
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 98 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 90 18322460
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 83 16809785
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 78 16809785
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 75 18981222
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 73 19941820
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 68 20980672
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 67 24448447
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 63 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 53 20980672
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 50 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 45 24448447
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 44 18981222
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 41 18322460
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 40 20980672
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 38 16809785
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 37 19941820
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 31 17537823
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 30 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 30 18981222
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 29 11804584
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 29 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 27 21536652
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 26 18981222
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 21 17537823
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 21 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 21 18981222
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 21 21536652
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 15 18322460
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 13 11991638
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 13 19935684
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 13 24448447
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 11 19941820
Prp8 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 10 19789211
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 8 22110043
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 4 19941820
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 1 19789211
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 1 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 1 23345524
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
tri-snRNP, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
tri-snRNP, S. cerevisiae, (Stevens et al 1999) S. cerevisiae ■ 11720284
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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