Nomenclature

Gene Symbol
CD2BP2 (H. sapiens)
Other Gene Symbols
FWP010, LIN1, PPP1R59, Snu40, U5-52K
Full Name
CD2 (cytoplasmic tail) binding protein 2
Other Names
U5-52kD, CD2 antigen (cytoplasmic tail) binding protein 2, CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, U5 snRNP 52K protein, protein phosphatase 1, regulatory subunit 59

Other Resources

Entrez: Gene Info
10421
Uniprot: Protein Info
CD2B2_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
115690
PDB: Structures
1GYF, 1L2Z, 1SYX
SpliProt3D: Structural Model
CD2BP2

Gene Product Info

Molecular Weight (kD)
37.6
Domains
GYF
Motifs
—
Features
—
Complex Association
tri-snRNP, U5 snRNP
Class / Family
U5 snRNP
Notes
—

Orthologs

Name Organism
LIN1 S. cerevisiae
CG5198 D. melanogaster
Y47D3A.27 C. elegans

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
CD2BP2 SNRPB Dervied from Literature — 15105431, 16000308
CD2BP2 PRPF6 Pull-down — 22365833
CD2BP2 PRPF6 Dervied from Literature — 15840814
CD2BP2 PRPF6 Y2H: Prey/Bait 0.5 22365833
CD2BP2 TXNL4A Dervied from Literature — 15840814
CD2BP2 WBP11 Dervied from Literature — 16000308
CD2BP2 SMU1 Y2H: Prey/Bait 0.4 22365833
CD2BP2 PPP1CA Y2H: Prey/Bait 0.5 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 139 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 28 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 28 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 18 18322460
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 18 21536652
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 18 27377154
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 15 21536652
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 11 24448447
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 10 21536652
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 10 27377154
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 8 20980672
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 8 27377154
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 5 18981222
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 5 20980672
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 5 18322460
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 5 16809785
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 5 16809785
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 5 27377154
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 4 18322460
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 4 20980672
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 4 16809785
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 4 24448447
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 4 27377154
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 3 24448447
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 2 18981222
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934

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