Nomenclature

Gene Symbol
SRRM2 (H. sapiens)
Other Gene Symbols
300-KD, CWF21, Cwc21, DKFZp667L0421, DKFZp686O15166
Full Name
serine/arginine repetitive matrix 2
Other Names
SRm300, 300 kDa nuclear matrix antigen, RNA binding protein, SR-related nuclear matrix protein of 300 kDa, ser/Arg-related nuclear matrix protein of 300 kDa, serine/arginine repetitive matrix protein 2

Other Resources

Entrez: Gene Info
23524
Uniprot: Protein Info
SRRM2_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
117071
PDB: Structures
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SpliProt3D: Structural Model
SRRM2

Gene Product Info

Molecular Weight (kD)
299.6
Domains
—
Motifs
—
Features
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Complex Association
C complex, P complex
Class / Family
SR related
Notes
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Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SRRM2 PRPF6 Y2H: Bait/Prey 0.68 22365833
SRRM2 SNIP1 Y2H: Bait/Prey 0.4 22365833
SRRM2 SRSF4 Y2H: Bait/Prey 0.4 22365833
SRRM2 SRRM1 Dervied from Literature — 9531537
SRRM2 TTC14 Y2H: Bait/Prey 0.52 22365833
SRRM2 PNN Dervied from Literature — 14578391

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 241 20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 194 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 189 20980672
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 162 27377154
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 145 20980672
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 91 27377154
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 76 18322460
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 71 16809785
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 71 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 69 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 66 27377154
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 63 24448447
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 52 18322460
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 51 21536652
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 47 23345524
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 46 18322460
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 41 23345524
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 33 18322460
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 32 27377154
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 25 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 22 24448447
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 17 11991638
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 16 21526149
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 14 16809785
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 13 18981222
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 12 18193060
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 12 17332742
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 12 12226669
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 10 24448447
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 9 12226669
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 9 18981222
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 8 22110043
SRM160 pulldown with BIC8 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 8 16159877
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 7 22110043
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 6 17095540
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 5 21526149
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 4 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 3 21536652
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
SRM160 pulldown with Srm160 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 1 16159877
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens ■ 24448447

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