Nomenclature

Gene Symbol
GNB2L1 (H. sapiens)
Other Gene Symbols
Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1
Full Name
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Other Names
RACK1, Receptor for Activated C Kinase 1, cell proliferation-inducing gene 21 protein, guanine nucleotide-binding protein subunit beta-2-like 1, guanine nucleotide-binding protein subunit beta-like protein 12.3, human lung cancer oncogene 7 protein

Other Resources

Entrez: Gene Info
10399
Uniprot: Protein Info
GBLP_HUMAN
Organism-Specific Database
BioGrid: Interaction Info
115671
PDB: Structures
SpliProt3D: Structural Model
GNB2L1

Gene Product Info

Molecular Weight (kD)
35.1
Domains
Motifs
Features
Class / Family
Occasionally detected in C complex
Notes

Orthologs

Name Organism
ASC1 S. cerevisiae
cpc2 S. pombe
Rack1 D. melanogaster
K04D7.1 C. elegans
PF08_0019 P. falciparum
GNB2L1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
GNB2L1 CHERP Y2H: Bait/Prey 1 22365833
GNB2L1 PRPF31 Y2H: Bait/Prey 0.71 22365833
GNB2L1 IK Y2H: Bidirectional 0.74 22365833
GNB2L1 DGCR14 Y2H: Bait/Prey 1 22365833
GNB2L1 WDR83 Y2H: Bait/Prey 0.67 22365833
GNB2L1 GNB2L1 Dervied from Literature 9442085
GNB2L1 PABPC1 Dervied from Literature 12388589
GNB2L1 HNRNPH2 Y2H: Bait/Prey 0.33 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 28 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 17 27377154
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 12 27377154
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 11 11804584
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 11 27377154
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 10 27377154
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 5 18322460
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 2 18322460
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 2 24448447
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 2 24448447
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 1 18981222
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 1 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens 12411573
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 24448447

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