Nomenclature

Gene Symbol
THOC1 (H. sapiens)
Other Gene Symbols
HPR1, P84, P84N5
Full Name
THO complex 1
Other Names
p84, THO complex subunit 1, hTREX84, nuclear matrix protein p84, tho1

Other Resources

Entrez: Gene Info
9984
Uniprot: Protein Info
THOC1_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
115305
PDB: Structures
1WXP
SpliProt3D: Structural Model
THOC1

Gene Product Info

Molecular Weight (kD)
75.7
Domains
Death
Motifs
Nuclear localization signal
Features
—
Class / Family
TREX
Notes
—

Orthologs

Name Organism
HPR1 S. cerevisiae
Hpr1 D. melanogaster
T02H6.2 C. elegans
THOC1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
THOC1 SF3B2 Y2H: Bait/Prey 0.62 22365833
THOC1 IK Y2H: Bait/Prey 0.94 22365833
THOC1 DHX8 Y2H: Bait/Prey 0.5 22365833
THOC1 THOC1 Y2H: Homodimer 0.5 22365833
THOC1 THOC5 Y2H: Bait/Prey 0.5 22365833
THOC1 THOC5 Dervied from Literature — 19059247
THOC1 SAP30BP Y2H: Bait/Prey 0.5 22365833
THOC1 FRA10AC1 Y2H: Bait/Prey 0.75 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 12 12226669
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 12 18322460
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 11 17537823
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 11 20980672
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 9 18322460
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 9 24448447
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 8 27377154
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 7 20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 7 20980672
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 7 27377154
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 6 12226669
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 6 17537823
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 6 27377154
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 5 18322460
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 5 20980672
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 5 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 5 24448447
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 4 11991638
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 4 27377154
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 4 27377154
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
mRNP unspliced control, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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