Nomenclature

Gene Symbol
PPIL1 (H. sapiens)
Other Gene Symbols
CGI-124, CYPL1, MGC678, PPIase, hCyPX
Full Name
peptidylprolyl isomerase (cyclophilin)-like 1
Other Names
PPIL1, cyclophilin-related gene 1, peptidyl-prolyl cis-trans isomerase, peptidyl-prolyl cis-trans isomerase-like 1, rotamase PPIL1

Other Resources

Entrez: Gene Info
51645
Uniprot: Protein Info
PPIL1_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
119654
PDB: Structures
1XWN, 2K7N, 2X7K
SpliProt3D: Structural Model
PPIL1

Gene Product Info

Molecular Weight (kD)
18.2
Domains
PPIase cyclophilin-type
Motifs
—
Features
—
Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 related
Notes
—

Orthologs

Name Organism
cyp1 S. pombe
Cypl D. melanogaster
C34D4.12 C. elegans
PFE1430c P. falciparum

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PPIL1 SF3B3 Y2H: Bait/Prey 0.5 22365833
PPIL1 SNW1 Dervied from Literature — 16595688
PPIL1 WDR83 Y2H: Bait/Prey 0.75 22365833
PPIL1 WDR83 Pull-down — 22365833
PPIL1 HNRNPUL1 Y2H: Bidirectional 0.81 22365833
PPIL1 THOC5 Y2H: Bait/Prey 0.5 22365833
PPIL1 RBM42 Y2H: Bait/Prey 0.5 22365833
PPIL1 HNRNPA1 Y2H: Bait/Prey 0.5 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 194 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 153 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 52 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 24 27377154
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 23 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 22 24448447
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 19 18322460
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 19 20980672
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 16 18322460
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 16 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 16 20980672
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 15 18322460
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 14 16809785
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 14 24448447
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 14 24448447
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 10 27377154
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 9 18322460
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 9 19761775
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 7 20980672
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 6 23345524
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 5 11991638
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 5 23345524
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 4 18981222
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 3 18981222
SRM160 pulldown with BIC8 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 3 16159877
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 3 27377154
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 2 19761775
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 2 17537823
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 1 16809785
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 1 21526149
SRM160 pulldown with Srm160 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 1 16159877
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 1 27377154
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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