Nomenclature

Gene Symbol
SNRPA1 (H. sapiens)
Other Gene Symbols
Lea1
Full Name
small nuclear ribonucleoprotein polypeptide A'
Other Names
U2-A', U2 small nuclear ribonucleoprotein A', U2 small nuclear ribonucleoprotein polypeptide A', U2 snRNP A'

Other Resources

Entrez: Gene Info
6627
Uniprot: Protein Info
RU2A_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112511
PDB: Structures
1A9N
SpliProt3D: Structural Model
SNRPA1

Gene Product Info

Molecular Weight (kD)
28.4
Domains
LRRCT
Motifs
—
Features
—
Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex
Class / Family
17S U2 snRNP
Notes
—

Orthologs

Name Organism
LEA1 S. cerevisiae
lea1 S. pombe
U2A D. melanogaster
H20J04.8 C. elegans
SNRPA1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SNRPA1 SNRPF Y2H: Prey/Bait 1 22365833
SNRPA1 SNRPA Y2H: Prey/Bait 1 22365833
SNRPA1 SNRPB2 Dervied from Literature — 9716128
SNRPA1 SNRPB2 Y2H: Prey/Bait 1 22365833
SNRPA1 SNRPB2 Pull-down — 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 262 21386897
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 260 21386897
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 216 21536652
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 215 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 181 21536652
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 180 21386897
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 169 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 115 21536652
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 85 20980672
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 82 27377154
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 74 20980672
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 67 16809785
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 66 27377154
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 65 19935684
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 65 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 65 27377154
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 62 20980672
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 59 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 55 18322460
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 51 19935684
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 48 24448447
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 47 19941820
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 47 19935684
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 47 27377154
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 45 16809785
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 41 16809785
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 39 18322460
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 32 20980672
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 32 19935684
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 31 17332742
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 30 19935684
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 29 18322460
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 28 19941820
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 27 19935684
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 26 18322460
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 26 24448447
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 24 23431055
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 23 21386897
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 23 23431055
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 22 19941820
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 20 18981222
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 19 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 19 23345524
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 18 18322460
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 18 18981222
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 18 24448447
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 17 19941820
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 16 19761775
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 16 20089683
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 16 23431055
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 15 20089683
Saf3 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 14 21386897
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 14 23431055
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 13 16809785
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 13 19935684
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 12 18322460
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 12 23431055
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 12 24448447
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 11 19941820
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 11 22110043
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 10 17537823
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 10 11804584
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 10 11884590
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 10 18193060
Urn1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 10 21386897
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 9 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 9 12226669
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 9 11991638
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 8 17537823
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 8 23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 8 23431055
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 7 20089683
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 7 22110043
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 7 21526149
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 6 11884590
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 6 18193060
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 6 22110043
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 6 23431055
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 5 11884590
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 5 11884590
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 5 21526149
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
CACN-1 pulldown with FLAG-HA tandem affinity from C. elegans, C. elegans, (Doherty et al 2014) C. elegans 5 24948787
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 4 11884590
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 4 11884590
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 4 19935684
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 3 19941820
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 3 19789211
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 2 19761775
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
Prp8 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 2 19789211
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 2 19935684
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 1 19935684
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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