Nomenclature

Gene Symbol
SNRPB2 (H. sapiens)
Other Gene Symbols
MGC24807, MGC45309, Msl1
Full Name
small nuclear ribonucleoprotein polypeptide B
Other Names
U2-B'', U2 small nuclear ribonucleoprotein B'', U2 snRNP B'', small nuclear ribonucleoprotein polypeptide B2

Other Resources

Entrez: Gene Info
6629
Uniprot: Protein Info
RU2B_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112513
PDB: Structures
1A9N
SpliProt3D: Structural Model
SNRPB2

Gene Product Info

Molecular Weight (kD)
25.5
Domains
RRM
Motifs
—
Features
—
Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex
Class / Family
17S U2 snRNP
Notes
—

Orthologs

Name Organism
MSL1 S. cerevisiae
msl1 S. pombe
K08D10.3 C. elegans
SNRPB2 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SNRPB2 SNRPA1 Y2H: Bait/Prey 1 22365833
SNRPB2 SNRPA1 Pull-down — 22365833
SNRPB2 SNRPA1 Dervied from Literature — 9716128
SNRPB2 HTATSF1 Dervied from Literature — 11780068
SNRPB2 SUGP1 Y2H: Bait/Prey 1 22365833
SNRPB2 SUGP1 Pull-down — 22365833
SNRPB2 DHX9 Dervied from Literature — 11149922
SNRPB2 HNRNPUL1 Y2H: Bait/Prey 0.5 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 251 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 222 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 133 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 131 21536652
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 114 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 45 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 39 27377154
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 33 20980672
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 31 16809785
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 30 20980672
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 28 16809785
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 27 20980672
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 27 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 25 18322460
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 25 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 24 27377154
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 22 19935684
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 21 27377154
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 20 20980672
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 17 16809785
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 17 24448447
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 15 18322460
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 14 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 14 24448447
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 14 24448447
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 13 18322460
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 13 19935684
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 13 23345524
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 12 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 12 19935684
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 12 24448447
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 10 19941820
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 10 19935684
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 10 23345524
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 9 19761775
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 9 19935684
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 8 19941820
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 8 17537823
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 8 17332742
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 7 18981222
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 7 11804584
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 7 23431055
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 7 23431055
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 5 18981222
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 5 19935684
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 5 22110043
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 4 18322460
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 4 20089683
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 4 19941820
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 4 17537823
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 4 22110043
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 4 21526149
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 4 21526149
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 4 23431055
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 4 23431055
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 3 20089683
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 3 20089683
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 3 22110043
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 2 19761775
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 2 11991638
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 2 19935684
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 1 11884590
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae ■ 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae ■ 19935684
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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