Nomenclature

Gene Symbol
SNRPA (H. sapiens)
Other Gene Symbols
Mud1, U1-A, U1A
Full Name
small nuclear ribonucleoprotein polypeptide A
Other Names
U1-A, U1 small nuclear RNP-specific A, U1 small nuclear ribonucleoprotein A, U1 snRNP A, U1 snRNP-specific protein A

Other Resources

Entrez: Gene Info
6626
Uniprot: Protein Info
SNRPA_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112510
PDB: Structures
1AUD, 1CX0, 1DRZ, 1DZ5, 1FHT
SpliProt3D: Structural Model
SNRPA

Gene Product Info

Molecular Weight (kD)
31.3
Domains
RRM
Motifs
—
Features
—
Complex Association
A complex, B complex, U1 snRNP
Class / Family
U1 snRNP
Notes
—

Orthologs

Name Organism
MUD1 S. cerevisiae
usp102 S. pombe
snf D. melanogaster
K08D10.4 C. elegans

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SNRPA SNRPA Dervied from Literature — 10688667, 10742179, 16189514
SNRPA SNRPA1 Y2H: Bait/Prey 1 22365833
SNRPA U2AF2 Y2H: Prey/Bait 0.75 22365833
SNRPA U2AF2 Pull-down — 22365833
SNRPA CDC5L Dervied from Literature — 11101529
SNRPA C19orf43 Dervied from Literature — 16189514
SNRPA C19orf43 Y2H: Prey/Bait 0.75 22365833
SNRPA RBM42 Y2H: Prey/Bait 0.75 22365833
SNRPA PTBP1 Dervied from Literature — 16189514
SNRPA PTBP1 Y2H: Prey/Bait 0.75 22365833
SNRPA PTBP2 Y2H: Prey/Bait 0.5 22365833
SNRPA HNRNPK Y2H: Bidirectional 0.84 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 205 21536652
U1 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 186 21536652
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 35 27377154
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 33 16809785
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 29 27377154
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 27 16809785
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 24 17332742
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 24 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 17 18322460
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 14 19941820
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 13 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 12 16809785
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 11 18193060
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 10 27377154
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 9 19935684
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 8 24448447
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 7 22110043
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 6 17537823
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 6 18193060
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 6 24448447
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 5 19941820
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 4 22110043
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 3 11804584
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 3 20980672
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 3 20980672
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 1 20980672
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
H complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
EDC complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
U1 snRNP, S. pombe, (Newo et al 2007) S. pombe ■ 17264129
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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