Nomenclature

Gene Symbol
U2AF2 (H. sapiens)
Other Gene Symbols
U2AF65
Full Name
U2 small nuclear RNA auxiliary factor 2
Other Names
U2AF65, U2 (RNU2) small nuclear RNA auxiliary factor 2, U2 auxiliary factor 65 kDa subunit, U2 small nuclear ribonucleoprotein auxiliary factor (65kD), U2 snRNP auxiliary factor large subunit, hU2AF(65)

Other Resources

Entrez: Gene Info
11338
Uniprot: Protein Info
U2AF2_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
116466
PDB: Structures
1JMT, 1O0P, 1OPI, 1U2F, 2G4B
SpliProt3D: Structural Model
U2AF2

Gene Product Info

Molecular Weight (kD)
53.5
Domains
RRM
Motifs
—
Features
—
Complex Association
A complex
Class / Family
17S U2 snRNP associated
Notes
—

Orthologs

Name Organism
MUD2 S. cerevisiae
prp2 S. pombe
U2af50 D. melanogaster
Y92C3B.2 C. elegans
PF14_0656 P. falciparum

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
U2AF2 SNRPA Y2H: Bait/Prey 0.75 22365833
U2AF2 SNRPA Pull-down — 22365833
U2AF2 SF3B1 Dervied from Literature — 9671485
U2AF2 U2AF1 Dervied from Literature — 1388271, 8647433, 9528748, 11551507, 16189514
U2AF2 U2AF1 Y2H: Bidirectional 1 22365833
U2AF2 PUF60 Y2H: Bait/Prey 0.62 22365833
U2AF2 PUF60 Dervied from Literature — 10866799, 16169070, 16189514
U2AF2 RBM17 Dervied from Literature — 17589525
U2AF2 CHERP Y2H: Bait/Prey 1 22365833
U2AF2 CHERP Pull-down — 22365833
U2AF2 SF1 Y2H: Bait/Prey 0.75 22365833
U2AF2 SF1 Dervied from Literature — 9150140, 9512519, 16189514
U2AF2 PRPF3 Y2H: Bait/Prey 0.88 22365833
U2AF2 PRPF3 Pull-down — 22365833
U2AF2 SRSF1 Dervied from Literature — 8261509, 9582097, 16189514
U2AF2 RBFOX2 Y2H: Bait/Prey 0.5 22365833
U2AF2 SRPK1 Dervied from Literature — 8798720
U2AF2 CCAR1 Y2H: Bait/Prey 0.5 22365833
U2AF2 SUGP1 Y2H: Bait/Prey 1 22365833
U2AF2 SUGP1 Pull-down — 22365833
U2AF2 RBM10 Pull-down — 22365833
U2AF2 RBM10 Y2H: Bidirectional 1 22365833
U2AF2 DDX17 Y2H: Bait/Prey 0.75 22365833
U2AF2 RBM39 Y2H: Bait/Prey 0.75 22365833
U2AF2 HNRNPA0 Y2H: Bait/Prey 0.5 22365833
U2AF2 HNRNPD Y2H: Bait/Prey 0.88 22365833
U2AF2 HNRNPK Y2H: Bait/Prey 0.62 22365833
U2AF2 KHDRBS3 Y2H: Bait/Prey 0.5 22365833
U2AF2 KHDRBS1 Y2H: Bait/Prey 0.75 22365833
U2AF2 RBM4 Y2H: Bait/Prey 0.75 22365833
U2AF2 QKI Y2H: Bait/Prey 0.75 22365833
U2AF2 DDX39B Dervied from Literature — 9242493
U2AF2 SAP30BP Y2H: Bidirectional 1 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 69 21536652
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 45 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 43 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 36 27377154
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 32 24448447
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 20 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 19 27377154
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 18 16809785
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 14 22110043
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 11 16809785
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 8 27377154
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 7 17537823
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 7 22110043
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 6 12226669
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 5 17332742
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 5 11991638
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 5 16809785
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 5 19935684
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 5 24448447
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 4 18322460
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 2 17537823
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 2 16809785
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 2 19935684
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 2 24448447
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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