Nomenclature

Gene Symbol
PRPF3 (H. sapiens)
Other Gene Symbols
HPRP3, HPRP3P, PRP3, Prp3p, RP18
Full Name
PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)
Other Names
HPRP3P, U4/U6 small nuclear ribonucleoprotein Prp3, U4/U6 snRNP 90 kDa protein, U4/U6-associated RNA splicing factor, pre-mRNA-splicing factor 3

Other Resources

Entrez: Gene Info
9129
Uniprot: Protein Info
PRPF3_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
114577
PDB: Structures
1X4Q
SpliProt3D: Structural Model
PRPF3

Gene Product Info

Molecular Weight (kD)
77.5
Domains
PWI
Motifs
—
Features
—
Complex Association
B complex, tri-snRNP, U4/U6 snRNP
Class / Family
U4/U6 snRNP
Notes
—

Orthologs

Name Organism
PRP3 S. cerevisiae
prp3 S. pombe
CG7757 D. melanogaster
M03C11.7 C. elegans
PRPF3 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PRPF3 SF3B2 Y2H: Bait/Prey 1 22365833
PRPF3 SF3B2 Pull-down — 22365833
PRPF3 U2AF2 Pull-down — 22365833
PRPF3 U2AF2 Y2H: Prey/Bait 0.88 22365833
PRPF3 SMNDC1 Pull-down — 22365833
PRPF3 SMNDC1 Dervied from Literature — 18211889
PRPF3 SMNDC1 Y2H: Prey/Bait 1 22365833
PRPF3 PRPF3 Y2H: Homodimer 1 22365833
PRPF3 PRPF3 Pull-down — 22365833
PRPF3 PRPF3 Pull-down — 22365833
PRPF3 SART1 Dervied from Literature — 16723661
PRPF3 CTNNBL1 Y2H: Prey/Bait 0.5 22365833
PRPF3 MFAP1 Pull-down — 22365833
PRPF3 MFAP1 Y2H: Bidirectional 0.97 22365833
PRPF3 SLU7 Y2H: Bait/Prey 0.75 22365833
PRPF3 SLU7 Pull-down — 22365833
PRPF3 SNIP1 Y2H: Bait/Prey 0.75 22365833
PRPF3 NKAP Y2H: Bait/Prey 0.5 22365833
PRPF3 NKAP Pull-down — 22365833
PRPF3 RBM39 Y2H: Bait/Prey 0.75 22365833
PRPF3 PCBP1 Y2H: Bait/Prey 0.5 22365833
PRPF3 FRA10AC1 Y2H: Bait/Prey 0.5 22365833
PRPF3 ZCCHC10 Y2H: Prey/Bait 1 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 255 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 186 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 116 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 97 27377154
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 85 16809785
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 85 27377154
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 84 21536652
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 82 16809785
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 77 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 75 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 73 24448447
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 67 18322460
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 63 18322460
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 49 24448447
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 43 16809785
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 41 18981222
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 34 18981222
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 32 21536652
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 29 11804584
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 27 18981222
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 27 19941820
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 20 16809785
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 17 20980672
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 17 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 15 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 15 18981222
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 14 22110043
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 13 20980672
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 13 17537823
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 12 24448447
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 11 19941820
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 11 18322460
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 9 12226669
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 8 17537823
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 8 21536652
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 5 12226669
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 3 18322460
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 3 20980672
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 3 24448447
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 2 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 1 21536652
tri-snRNP, S. cerevisiae, (Stevens et al 1999) S. cerevisiae ■ 11720284
tri-snRNP, S. cerevisiae, (Gottschalk et al 1999) S. cerevisiae ■ 10449419
tri-snRNP, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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