Nomenclature

Gene Symbol
SLU7 (H. sapiens)
Other Gene Symbols
9G8, MGC9280, hSlu7
Full Name
SLU7 splicing factor homolog (S. cerevisiae)
Other Names
SLU7, pre-mRNA-splicing factor SLU7, splicing factor, step II splicing factor SLU7, zinc knuckle motif containing

Other Resources

Entrez: Gene Info
10569
Uniprot: Protein Info
SLU7_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
115820
PDB: Structures
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SpliProt3D: Structural Model
SLU7

Gene Product Info

Molecular Weight (kD)
68.4
Domains
—
Motifs
Bipartite nuclear localization signal
Features
—
Complex Association
C complex, P complex
Class / Family
Second step factors
Notes
—

Orthologs

Name Organism
SLU7 S. cerevisiae
slu7 S. pombe
Slu7 D. melanogaster
K07C5.6 C. elegans
SLU7 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SLU7 SF3B2 Y2H: Bait/Prey 0.55 22365833
SLU7 SF3B2 Pull-down — 22365833
SLU7 PRPF8 Pull-down — 22365833
SLU7 PRPF8 Y2H: Prey/Bait 0.78 22365833
SLU7 PRPF3 Pull-down — 22365833
SLU7 PRPF3 Y2H: Prey/Bait 0.75 22365833
SLU7 PPIL3 Dervied from Literature — 16189514
SLU7 PPIL3 Y2H: Bidirectional 1 22365833
SLU7 PPIG Y2H: Prey/Bait 0.5 22365833
SLU7 PCBP2 Y2H: Prey/Bait 0.33 22365833
SLU7 BAG2 Y2H: Prey/Bait 0.33 22365833
SLU7 ZCCHC10 Y2H: Prey/Bait 1 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 94 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 72 20980672
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 53 18322460
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 51 21536652
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 50 24448447
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 31 18322460
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 31 24448447
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 27 18322460
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 24 23345524
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 17 19941820
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 16 19761775
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 16 23345524
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 13 20089683
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 10 19935684
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 9 11991638
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 8 17537823
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 3 19761775
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 2 20980672
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 2 11884590
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 2 21526149
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 1 16809785
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 1 16809785
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens ■ 24448447

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