Nomenclature

Gene Symbol
DDX17 (H. sapiens)
Other Gene Symbols
DKFZp761H2016, P72, RH70
Full Name
DEAD (Asp-Glu-Ala-Asp) box helicase 17
Other Names
p72 DEAD, DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, DEAD box protein p72, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD), RNA-dependent helicase p72, probable ATP-dependent RNA helicase DDX17

Other Resources

Entrez: Gene Info
10521
Uniprot: Protein Info
DDX17_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
115776
PDB: Structures
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SpliProt3D: Structural Model
DDX17

Gene Product Info

Molecular Weight (kD)
80.3
Domains
Helicase ATP-binding, Helicase C-terminal
Motifs
DEAD box, Q motif
Features
—
Class / Family
pre-mRNA/mRNA binding proteins
Notes
—

Orthologs

Name Organism
Rm62 D. melanogaster
DDX17 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
DDX17 SNRNP70 Dervied from Literature — 12193588
DDX17 SF3B4 Y2H: Prey/Bait 0.75 22365833
DDX17 U2AF2 Y2H: Prey/Bait 0.75 22365833
DDX17 SF1 Y2H: Bait/Prey 0.75 22365833
DDX17 SF1 Dervied from Literature — 16189514
DDX17 WBP11 Y2H: Bait/Prey 0.75 22365833
DDX17 WBP11 Dervied from Literature — 16189514
DDX17 DDX17 Y2H: Homodimer 0.5 22365833
DDX17 HNRNPH3 Y2H: Prey/Bait 0.5 22365833
DDX17 HNRNPK Y2H: Bidirectional 0.7 22365833
DDX17 DDX5 Dervied from Literature — 12595555
DDX17 DDX5 Y2H: Bidirectional 0.75 22365833
DDX17 RBM4 Y2H: Bait/Prey 0.75 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 23 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 21 24448447
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 19 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 19 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 18 18981222
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 15 18981222
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 14 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 14 18981222
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 13 18193060
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 13 17537823
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 12 27377154
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 11 18193060
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 11 17537823
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 10 18981222
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 8 12226669
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 7 11991638
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 6 24448447
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 6 27377154
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 5 11991638
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 3 16809785
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 3 23345524
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 3 22110043
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 3 24448447
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 2 23345524
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 1 16809785
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
H complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
EDC complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, without splicing substrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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