Nomenclature

Gene Symbol
SF3B1 (H. sapiens)
Other Gene Symbols
Hsh155, MDS, PRP10, PRPF10, SAP155
Full Name
splicing factor 3b, subunit 1, 155kDa
Other Names
SF3b155, SAP 155, pre-mRNA processing 10, pre-mRNA splicing factor SF3b, 155 kDa subunit, pre-mRNA-splicing factor SF3b 155 kDa subunit, spliceosome associated protein 155

Other Resources

Entrez: Gene Info
23451
Uniprot: Protein Info
SF3B1_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
117017
PDB: Structures
2F9D, 2F9J, 2FHO, 2PEH, 3LQV
SpliProt3D: Structural Model
SF3B1

Gene Product Info

Molecular Weight (kD)
145.8
Domains
—
Motifs
—
Features
—
Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex
Class / Family
17S U2 snRNP
Notes
—

Orthologs

Name Organism
HSH155 S. cerevisiae
prp10 S. pombe
CG2807 D. melanogaster
T08A11.2 C. elegans
SF3B1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SF3B1 SF3B3 Dervied from Literature — 10490618
SF3B1 SF3B6 Dervied from Literature — 11500380, 16495236
SF3B1 SF3B6 Y2H: Prey/Bait 1 22365833
SF3B1 U2AF1 Dervied from Literature — 9671485
SF3B1 U2AF2 Dervied from Literature — 9671485
SF3B1 RBM17 Dervied from Literature — 17589525
SF3B1 RBM17 Y2H: Prey/Bait 0.5 22365833
SF3B1 RBM17 Pull-down — 22365833
SF3B1 PLRG1 Y2H: Prey/Bait 0.75 22365833
SF3B1 SNIP1 Dervied from Literature — 15231748
SF3B1 SNIP1 Y2H: Prey/Bait 0.75 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 740 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 559 27377154
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 254 19935684
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 222 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 215 27377154
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 208 20980672
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 206 27377154
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 194 20980672
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 188 27377154
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 173 19935684
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 155 23431055
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 153 18322460
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 143 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 137 19935684
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 133 21536652
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 132 19935684
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 130 24448447
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 128 23431055
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 121 19935684
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 120 21536652
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 119 18322460
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 114 23431055
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 114 24448447
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 113 21386897
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 111 16809785
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 110 19935684
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 109 16809785
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 109 21536652
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 106 23431055
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 103 23431055
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 102 18981222
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 93 19941820
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 83 19941820
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 79 21536652
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 75 20980672
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 73 23431055
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 69 17332742
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 59 16809785
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 58 22110043
Saf3 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 57 21386897
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 57 23431055
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 55 22110043
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 54 18981222
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 54 20980672
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 54 18981222
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 54 21386897
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 54 23431055
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 53 23431055
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 49 18981222
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 49 23431055
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 48 18322460
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 48 18981222
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 45 22110043
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 43 23345524
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 41 19935684
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 37 18981222
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 37 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 36 19935684
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 35 17537823
Urn1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 30 21386897
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 30 24448447
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 29 18193060
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 29 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 29 16809785
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 29 21536652
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 28 18322460
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 28 23345524
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 27 23431055
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 26 17537823
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 26 18193060
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 25 12226669
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 24 19941820
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 24 24448447
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 23 19941820
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 22 18322460
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 22 18193060
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 22 19941820
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 22 21526149
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 21 18193060
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 20 20089683
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 20 12226669
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 18 18193060
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 16 19941820
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 16 18981222
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 15 18981222
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 15 18193060
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 14 18193060
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 14 18193060
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 10 23431055
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 9 11804584
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 9 19761775
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 8 11884590
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 7 11991638
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 4 19761775
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 4 11884590
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 4 12509417
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
H complex, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 2 11991638
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
Released from Post-catalytic complex, deltaPrp22, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
SF3b, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

©2011 Spliceosome Component Database  All Rights Reserved.
design by juricalab