Nomenclature

Gene Symbol
SF3B6 (H. sapiens)
Other Gene Symbols
SF3B14, CGI-110, HSPC175, Ht006, P14, SAP14
Full Name
p14
Other Names
p14, SF3b 14 kDa subunit, pre-mRNA branch site protein p14, spliceosome-associated protein, 14 kDa subunit

Other Resources

Entrez: Gene Info
51639
Uniprot: Protein Info
SF3B6_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
119651
PDB: Structures
2F9D, 2F9J, 2FHO, 3LQV
SpliProt3D: Structural Model
SF3B14

Gene Product Info

Molecular Weight (kD)
14.6
Domains
RRM
Motifs
—
Features
—
Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex
Class / Family
17S U2 snRNP
Notes
—

Orthologs

Name Organism
Pre-mRNA branch site p14-like protein S. pombe
CG13298 D. melanogaster
C50D2.5 C. elegans
PFL1200c P. falciparum
SF3B14 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SF3B6 SF3B1 Y2H: Bait/Prey 1 22365833
SF3B6 SF3B1 Dervied from Literature — 11500380, 16495236
SF3B6 SF3B3 Dervied from Literature — 11500380
SF3B6 SNIP1 Dervied from Literature — 15231748

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 203 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 175 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 145 21536652
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 81 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 63 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 48 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 40 27377154
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 30 16809785
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 29 20980672
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 29 20980672
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 29 27377154
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 23 17332742
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 22 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 21 27377154
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 20 16809785
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 18 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 17 18322460
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 15 24448447
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 15 24448447
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 14 18981222
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 12 16809785
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 11 20980672
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 8 22110043
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 8 22110043
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 7 16809785
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 7 23345524
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 6 18981222
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 6 20980672
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 6 22110043
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 6 24448447
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 5 17537823
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 4 23345524
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 3 18322460
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
SF3b, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920

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