Nomenclature

Gene Symbol
PLRG1 (H. sapiens)
Other Gene Symbols
Cwc1, MGC110980, PRL1, PRP46, PRPF46
Full Name
pleiotropic regulator 1
Other Names
PRL1, pleiotropic regulator 1, pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)

Other Resources

Entrez: Gene Info
5356
Uniprot: Protein Info
PLRG1_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
111370
PDB: Structures
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SpliProt3D: Structural Model
PLRG1

Gene Product Info

Molecular Weight (kD)
57.2
Domains
—
Motifs
—
Features
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Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 complex
Notes
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Orthologs

Name Organism
PRP46 S. cerevisiae
prp5 S. pombe
Tango4 D. melanogaster
D1054.15 C. elegans
PLRG1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PLRG1 SF3B1 Y2H: Bait/Prey 0.75 22365833
PLRG1 CDC5L Dervied from Literature — 11544257, 14576297

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 809 21386897
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 763 21386897
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 455 21386897
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 207 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 183 21536652
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 170 19935684
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 155 27377154
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 115 20980672
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 99 19935684
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 97 19941820
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 88 20980672
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 85 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 81 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 75 19935684
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 72 20980672
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 71 19935684
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 69 19935684
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 63 18322460
Urn1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 63 21386897
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 60 20980672
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 59 23431055
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 55 19935684
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 54 23431055
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 53 23431055
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 52 19935684
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 51 21536652
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 50 19935684
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 50 23431055
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 44 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 43 24448447
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 41 23431055
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 41 27377154
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 40 24448447
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 38 23431055
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 37 23431055
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 35 19941820
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 33 20089683
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 32 18322460
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 29 18981222
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 29 23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 29 23431055
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 28 19941820
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 28 18322460
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 27 27377154
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 25 20089683
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 24 23431055
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 24 24448447
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 22 18322460
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 22 11884590
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 21 23431055
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 20 11884590
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 20 19941820
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 20 11884590
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 20 19941820
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 20 16809785
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 19 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 19 16809785
Aim4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 18 21386897
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 16 20089683
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 16 11884590
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 16 11991638
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 15 17537823
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 15 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 15 23345524
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 15 24448447
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 14 19761775
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 14 11884590
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 14 18981222
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 13 11884590
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 13 18981222
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 13 16809785
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 12 27377154
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 10 18322460
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 10 19761775
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 9 19941820
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 9 18981222
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 9 21386897
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 7 11804584
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 7 12226669
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 7 21526149
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 7 23431055
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 6 12509417
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 2 16809785
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 2 19789211
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
Prp8 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 1 19789211
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 1 21526149
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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