Nomenclature

Gene Symbol
PRPF19 (H. sapiens)
Other Gene Symbols
NMP200, PRP19, PSO4, SNEV, UBOX4
Full Name
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
Other Names
PRP19, PRP19/PSO4 homolog, nuclear matrix protein 200, nuclear matrix protein NMP200 related to splicing factor PRP19, pre-mRNA-processing factor 19, senescence evasion factor

Other Resources

Entrez: Gene Info
27339
Uniprot: Protein Info
PRP19_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
118151
PDB: Structures
—
SpliProt3D: Structural Model
PRPF19

Gene Product Info

Molecular Weight (kD)
55.2
Domains
U-box
Motifs
—
Features
—
Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 complex
Notes
—

Orthologs

Name Organism
PRP19 S. cerevisiae
prp19 S. pombe
Prp19 D. melanogaster
T10F2.4 C. elegans
PRPF19 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PRPF19 DDX42 Y2H: Bait/Prey 1 22365833
PRPF19 U2AF1 Y2H: Bait/Prey 0.75 22365833
PRPF19 PRPF8 Y2H: Bait/Prey 0.33 22365833
PRPF19 PRPF8 Pull-down — 22365833
PRPF19 BCAS2 Y2H: Bait/Prey 0.75 22365833
PRPF19 BCAS2 Dervied from Literature — 20176811
PRPF19 BCAS2 Pull-down — 22365833
PRPF19 PRCC Y2H: Bait/Prey 1 22365833
PRPF19 CDC40 Y2H: Bait/Prey 1 22365833
PRPF19 CDC40 Pull-down — 22365833
PRPF19 RBM5 Y2H: Bait/Prey 0.75 22365833
PRPF19 RBM5 Pull-down — 22365833
PRPF19 RBM10 Y2H: Bait/Prey 1 22365833
PRPF19 RBM10 Pull-down — 22365833
PRPF19 HSPB1 Y2H: Bait/Prey 1 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 929 21386897
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 852 21386897
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 833 21386897
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 519 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 476 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 293 21536652
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 277 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 272 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 244 19935684
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 235 19941820
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 196 27377154
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 195 19941820
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 193 19935684
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 173 20980672
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 167 18322460
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 167 20980672
Urn1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 166 21386897
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 165 23431055
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 163 19935684
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 152 20980672
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 152 19935684
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 150 19941820
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 146 20980672
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 138 18322460
Aim4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 132 21386897
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 125 24448447
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 107 19935684
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 100 23431055
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 96 18322460
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 96 19935684
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 91 19935684
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 90 23431055
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 87 24448447
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 84 23431055
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 83 23431055
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 81 23431055
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 80 18322460
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 72 24448447
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 68 23431055
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 60 23431055
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 57 19935684
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 55 16809785
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 50 19941820
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 50 16809785
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 50 27377154
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 49 19941820
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 49 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 46 16809785
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 46 27377154
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 44 20089683
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 44 18981222
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 43 20089683
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 40 16809785
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 39 18322460
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 39 23431055
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 37 18981222
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 36 27377154
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 33 23431055
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 32 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 32 23345524
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 32 23431055
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 31 19941820
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 29 24448447
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 28 20089683
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 26 19761775
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 26 21526149
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 24 18981222
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 24 11884590
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 23 18322460
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 22 11884590
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 22 18981222
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 21 11991638
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 21 18981222
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 21 21386897
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 18 11884590
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 18 18981222
Saf1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 18 21386897
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 17 11884590
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 17 11884590
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 16 18981222
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 15 11884590
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 15 17537823
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 15 18981222
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 14 19761775
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 14 12509417
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 14 21536652
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 13 11804584
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 13 17537823
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 12 27377154
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 10 12226669
Saf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 10 21386897
CACN-1 pulldown with FLAG-HA tandem affinity from C. elegans, C. elegans, (Doherty et al 2014) C. elegans 9 24948787
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 7 12226669
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 7 22110043
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 7 21526149
Released from Post-catalytic complex, deltaPrp22, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 7 23431055
SRM160 pulldown with BIC8 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 5 16159877
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 4 11991638
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 3 22110043
SRM300 pulldown with Srm300 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 2 16159877
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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