Nomenclature

Gene Symbol
PRPF38A (H. sapiens)
Other Gene Symbols
FLJ14936, MGC3320, Prp38, RP5-965L7.1
Full Name
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
Other Names
hPRP38A, pre-mRNA-splicing factor 38A

Other Resources

Entrez: Gene Info
84950
Uniprot: Protein Info
PR38A_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
124382
PDB: Structures
—
SpliProt3D: Structural Model
PRPF38A

Gene Product Info

Molecular Weight (kD)
37.5
Domains
—
Motifs
—
Features
—
Complex Association
B complex
Class / Family
Recruited at B complex
Notes
—

Orthologs

Name Organism
PRP38 S. cerevisiae
prp38 S. pombe
Prp38 D. melanogaster
D1054.14 C. elegans
PRPF38A G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PRPF38A U2AF1 Y2H: Bait/Prey 1 22365833
PRPF38A CHERP Y2H: Bidirectional 1 22365833
PRPF38A PRPF38A Y2H: Homodimer 0.5 22365833
PRPF38A DHX8 Y2H: Bait/Prey 0.5 22365833
PRPF38A PPIG Y2H: Bait/Prey 0.75 22365833
PRPF38A RNPS1 Y2H: Bidirectional 0.75 22365833
PRPF38A SRSF4 Y2H: Bait/Prey 0.75 22365833
PRPF38A SRPK1 Y2H: Prey/Bait 0.67 22365833
PRPF38A SRSF3 Y2H: Bait/Prey 0.5 22365833
PRPF38A RBM39 Y2H: Bait/Prey 0.5 22365833
PRPF38A ZCCHC10 Y2H: Prey/Bait 1 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 83 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 40 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 32 21536652
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 32 27377154
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 31 20980672
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 30 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 28 24448447
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 24 16809785
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 23 20980672
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 21 19941820
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 19 18981222
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 17 18322460
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 13 18981222
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 13 24448447
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 11 16809785
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 11 27377154
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 10 18981222
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 10 27377154
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 9 24448447
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 8 19941820
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 8 20980672
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 7 11804584
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 7 19935684
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 6 23345524
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 6 24448447
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 5 17537823
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 4 18322460
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 3 19941820
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 3 20980672
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 3 17537823
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 3 16809785
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 3 23345524
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 2 11991638
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
tri-snRNP, S. cerevisiae, (Gottschalk et al 1999) S. cerevisiae ■ 10449419
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

©2011 Spliceosome Component Database  All Rights Reserved.
design by juricalab