Nomenclature

Gene Symbol
PRPF40A (H. sapiens)
Other Gene Symbols
FBP-11, FBP11, FLAF1, FLJ20585, FNBP3
Full Name
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
Other Names
hFBP3 , Fas-ligand associated factor 1, Huntingtin-interacting protein A, NY-REN-6 antigen, fas ligand-associated factor 1, formin binding protein 3

Other Resources

Entrez: Gene Info
55660
Uniprot: Protein Info
PR40A_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
120792
PDB: Structures
1UZC, 1YWI, 1YWJ, 1ZR7, 2CQN
SpliProt3D: Structural Model
PRPF40A

Gene Product Info

Molecular Weight (kD)
108.8
Domains
FF, WW
Motifs
—
Features
—
Complex Association
A complex
Class / Family
Recruited at A complex
Notes
—

Orthologs

Name Organism
PRP40 S. cerevisiae
usp104 S. pombe
CG3542 D. melanogaster
ZK1098.1 C. elegans
PRPF40A G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PRPF40A SNRNP70 Dervied from Literature — 15231748
PRPF40A SF3B2 Y2H: Bait/Prey 1 22365833
PRPF40A SF3A1 Y2H: Bait/Prey 0.5 22365833
PRPF40A SF3A1 Pull-down — 22365833
PRPF40A U2AF1 Y2H: Bait/Prey 0.81 22365833
PRPF40A U2SURP Y2H: Bidirectional 0.88 22365833
PRPF40A CHERP Y2H: Bidirectional 0.88 22365833
PRPF40A PRPF40A Y2H: Homodimer 0.75 22365833
PRPF40A PRPF40A Dervied from Literature — 9700202
PRPF40A DHX8 Y2H: Bidirectional 1 22365833
PRPF40A PPIG Y2H: Bidirectional 0.94 22365833
PRPF40A SNIP1 Y2H: Bait/Prey 0.75 22365833
PRPF40A SRPK1 Dervied from Literature — 9171351
PRPF40A NKAP Pull-down — 22365833
PRPF40A NKAP Y2H: Bidirectional 1 22365833
PRPF40A HNRNPUL1 Dervied from Literature — 15231748, 16169070
PRPF40A RBMX2 Y2H: Prey/Bait 0.67 22365833
PRPF40A RBM39 Y2H: Bait/Prey 0.5 22365833
PRPF40A PCBP2 Dervied from Literature — 15231748
PRPF40A ZCCHC10 Y2H: Prey/Bait 1 22365833
PRPF40A FRA10AC1 Y2H: Bidirectional 0.81 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 24 16809785
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 21 19935684
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 19 19941820
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 17 16809785
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 13 18981222
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 12 19941820
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 10 17332742
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 10 21536652
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 9 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 9 12226669
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 9 22110043
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 9 22110043
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 8 19935684
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 7 11804584
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 7 20980672
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 6 27377154
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 5 22110043
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 5 24448447
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 4 19941820
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 3 17537823
SRM300 pulldown with Srm300 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 3 16159877
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 3 27377154
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 2 17537823
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
SRM160 pulldown with Srm160 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 2 16159877
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 2 27377154
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 1 20980672
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
U1 snRNP, S. pombe, (Newo et al 2007) S. pombe ■ 17264129
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens ■ 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens ■ 24448447

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