Nomenclature

Gene Symbol
RBM22 (H. sapiens)
Other Gene Symbols
Cwc2, FLJ10290, ZC3H16, fSAP47
Full Name
RNA binding motif protein 22
Other Names
RBM22, RNA-binding motif protein 22, functional spliceosome-associated protein 47, pre-mRNA-splicing factor RBM22, zinc finger CCCH domain-containing protein 16

Other Resources

Entrez: Gene Info
55696
Uniprot: Protein Info
RBM22_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
120821
PDB: Structures
2YTC
SpliProt3D: Structural Model
RBM22

Gene Product Info

Molecular Weight (kD)
46.9
Domains
RRM
Motifs
—
Features
—
Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 related
Notes
—

Orthologs

Name Organism
ECM2 S. cerevisiae
cwf5 S. pombe
CG14641 D. melanogaster
T11G6.8 C. elegans
RBM22 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
RBM22 AQR Y2H: Prey/Bait 0.53 22365833
RBM22 RBFOX2 Y2H: Bait/Prey 0.75 22365833
RBM22 HNRNPUL1 Y2H: Bait/Prey 0.92 22365833
RBM22 RBM4 Y2H: Bait/Prey 1 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 490 21386897
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 445 21386897
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 425 21386897
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 254 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 175 21536652
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 97 20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 90 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 86 20980672
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 81 19935684
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 73 21536652
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 56 19935684
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 54 18322460
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 50 19935684
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 48 24448447
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 47 23431055
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 46 20980672
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 44 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 44 24448447
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 43 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 41 19935684
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 41 27377154
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 37 19935684
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 35 19941820
Saf1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 34 21386897
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 34 19935684
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 34 23431055
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 33 23431055
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 32 19941820
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 30 19935684
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 29 18322460
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 29 18981222
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 26 19941820
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 26 19935684
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 25 24448447
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 24 19935684
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 22 18322460
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 22 18981222
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 20 23431055
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 18 23431055
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 17 20089683
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 17 18981222
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 17 23431055
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 16 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 16 23345524
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 16 23431055
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 16 27377154
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 15 20089683
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 15 11884590
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 15 16809785
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 14 23431055
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 11 11884590
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 11 18322460
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 10 19761775
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 8 11884590
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 8 11884590
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 8 24448447
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 7 20089683
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 6 17537823
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 6 18981222
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 6 19761775
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 6 11991638
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 6 21526149
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 5 19941820
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 5 11884590
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 5 18981222
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 5 21386897
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 4 12509417
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
CACN-1 pulldown with FLAG-HA tandem affinity from C. elegans, C. elegans, (Doherty et al 2014) C. elegans 3 24948787
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 2 27377154
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 1 11804584
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 1 16809785
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 1 27377154
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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