Nomenclature

Gene Symbol
CWC2 (S. cerevisiae)
Other Gene Symbols
NTC40
Full Name
Cwc2p
Other Names
CWC2, YDL209C

Other Resources

Entrez: Gene Info
851318
Uniprot: Protein Info
CWC2_YEAST
Organism-Specific Database
S000002368
BioGrid: Interaction Info
31837
PDB: Structures
3TP2, 3U1L, 3U1M
SpliProt3D: Structural Model
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Gene Product Info

Molecular Weight (kD)
38.4
Domains
RRM
Motifs
—
Features
—
Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 related
Notes
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Orthologs

Name Organism
RBM22 H. sapiens
cwf2 S. pombe
CG14641 D. melanogaster
T11G6.8 C. elegans
RBM22 G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 530 21386897
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 437 21386897
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 341 21386897
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 254 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 175 21536652
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 100 19935684
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 97 20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 90 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 86 20980672
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 73 21536652
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 73 23431055
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 60 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 56 19935684
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 54 18322460
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 48 24448447
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 46 20980672
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 45 19941820
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 44 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 44 24448447
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 43 19941820
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 43 19935684
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 42 19935684
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 41 27377154
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 40 19935684
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 40 19935684
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 39 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 38 19935684
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 29 18322460
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 29 18981222
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 28 23431055
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 27 23431055
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 26 19935684
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 26 23431055
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 25 23431055
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 25 23431055
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 25 24448447
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 22 18322460
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 22 18981222
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 22 23431055
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 22 23431055
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 20 20089683
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 19 19941820
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 19 20089683
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 19 23431055
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 17 18981222
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 16 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 16 23345524
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 16 27377154
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 15 16809785
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 14 20089683
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 11 11804584
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 11 18322460
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 11 11884590
Saf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 11 21386897
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 10 11884590
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 10 19761775
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 9 19941820
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 9 23431055
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 8 23431055
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 8 24448447
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 7 23431055
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 6 17537823
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 6 18981222
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 6 19761775
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 6 11991638
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 6 21386897
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 6 21526149
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 5 11884590
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 5 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 3 12509417
CACN-1 pulldown with FLAG-HA tandem affinity from C. elegans, C. elegans, (Doherty et al 2014) C. elegans 3 24948787
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 2 19789211
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 2 27377154
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 1 16809785
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 1 27377154
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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