Nomenclature

Gene Symbol
prp12 (S. pombe)
Other Gene Symbols
—
Full Name
U2 snRNP-associated protein Sap130 (predicted)
Other Names
—, SPAPJ698.03c

Other Resources

Entrez: Gene Info
2543278
Uniprot: Protein Info
RSE1_SCHPO
Organism-Specific Database
—
BioGrid: Interaction Info
279706
PDB: Structures
—
SpliProt3D: Structural Model
—

Gene Product Info

Molecular Weight (kD)
135.0
Domains
—
Motifs
—
Features
—
Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex
Class / Family
17S U2 snRNP
Notes
—

Orthologs

Name Organism
SF3B3 H. sapiens
RSE1 S. cerevisiae
CG13900 D. melanogaster
K02F2.3 C. elegans
SF3B3 G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 950 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 833 27377154
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 351 20980672
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 336 20980672
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 255 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 254 18322460
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 252 16809785
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 236 24448447
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 236 27377154
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 232 27377154
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 224 19935684
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 216 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 209 18322460
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 169 19935684
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 161 24448447
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 160 17332742
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 160 19935684
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 153 23431055
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 148 21536652
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 147 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 146 19935684
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 146 23431055
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 143 19935684
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 131 21536652
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 128 19935684
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 128 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 128 21536652
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 121 16809785
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 119 19935684
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 117 23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 113 23431055
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 111 19941820
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 105 20980672
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 103 23431055
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 98 20980672
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 93 16809785
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 91 19941820
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 90 21386897
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 71 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 68 18981222
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 68 23431055
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 67 18322460
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 67 23431055
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 66 18981222
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 66 23431055
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 65 23431055
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 63 19941820
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 63 24448447
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 61 19941820
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 61 23431055
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 60 18981222
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 58 21386897
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 52 19941820
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 50 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 50 18981222
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 49 19935684
Saf3 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 45 21386897
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 44 19935684
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 44 21536652
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 42 18322460
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 39 23345524
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 36 18981222
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 32 19941820
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 31 22110043
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 30 18193060
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 30 18981222
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 29 23345524
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 29 24448447
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 28 19761775
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 28 18981222
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 26 18322460
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 25 22110043
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 24 18193060
Urn1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 24 21386897
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 23 17537823
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 23 22110043
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 20 20089683
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 20 23431055
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 19 18193060
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 15 18193060
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 15 18193060
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 15 21526149
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 14 18193060
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 14 17537823
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 12 19761775
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 11 16809785
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 8 11991638
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 6 11804584
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 5 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 5 12226669
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 5 11884590
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 4 21526149
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 3 12509417
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 2 11991638
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
H complex, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
SF3b, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, without splicing substrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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