Nomenclature

Gene Symbol
PRPF31 (H. sapiens)
Other Gene Symbols
DKFZp566J153, NY-BR-99, PRP31, RP11
Full Name
PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)
Other Names
PRP31, U4/U6 small nuclear ribonucleoprotein Prp31, U4/U6 snRNP 61 kDa protein, hPrp31, pre-mRNA-processing factor 31, protein 61K

Other Resources

Entrez: Gene Info
26121
Uniprot: Protein Info
PRP31_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
117563
PDB: Structures
2OZB, 3SIU, 3SIV
SpliProt3D: Structural Model
PRPF31

Gene Product Info

Molecular Weight (kD)
55.5
Domains
Nop
Motifs
—
Features
—
Complex Association
B complex, tri-snRNP, U4/U6 snRNP
Class / Family
U4/U6 snRNP
Notes
—

Orthologs

Name Organism
PRP31 S. cerevisiae
prp31 S. pombe
Prp31 D. melanogaster
Y110A7A.8 C. elegans

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PRPF31 PHF5A Y2H: Bait/Prey 0.85 22365833
PRPF31 RBM25 Y2H: Bidirectional 1 22365833
PRPF31 PRPF6 Y2H: Bait/Prey 0.66 22365833
PRPF31 PRPF6 Pull-down — 22365833
PRPF31 PRPF6 Dervied from Literature — 16723661, 17412961
PRPF31 GNB2L1 Y2H: Prey/Bait 0.71 22365833
PRPF31 RBM4 Y2H: Bait/Prey 0.67 22365833
PRPF31 HNRNPH2 Y2H: Prey/Bait 0.39 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 122 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 99 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 79 21536652
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 62 16809785
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 62 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 60 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 58 24448447
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 53 16809785
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 44 27377154
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 42 18981222
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 39 16809785
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 39 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 33 27377154
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 31 21536652
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 27 19941820
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 27 18322460
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 27 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 22 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 22 18981222
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 19 24448447
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 17 18981222
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 15 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 15 18981222
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 12 11804584
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 12 16809785
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 11 19941820
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 10 18322460
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 10 20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 10 20980672
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 9 24448447
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 8 17537823
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 7 20980672
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 5 17537823
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 4 18322460
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 4 17095540
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 4 22110043
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
tri-snRNP, S. cerevisiae, (Gottschalk et al 1999) S. cerevisiae ■ 10449419
tri-snRNP, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
tri-snRNP, S. cerevisiae, (Stevens et al 1999) S. cerevisiae ■ 11720284
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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