Nomenclature

Gene Symbol
PHF5A (H. sapiens)
Other Gene Symbols
INI, MGC1346, Rds3, SAP14b, SF3b14b
Full Name
PHD finger protein 5A
Other Names
SF3b14b, PHD finger-like domain protein 5A, PHD finger-like domain-containing protein 5A, PHD-finger 5a, splicing factor 3B associated 14 kDa protein, splicing factor 3B-associated 14 kDa protein

Other Resources

Entrez: Gene Info
84844
Uniprot: Protein Info
PHF5A_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
124296
PDB: Structures
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SpliProt3D: Structural Model
PHF5A

Gene Product Info

Molecular Weight (kD)
12.4
Domains
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Motifs
—
Features
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Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex
Class / Family
17S U2 snRNP
Notes
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Orthologs

Name Organism
RDS3 S. cerevisiae
ini1 S. pombe
CG9548 D. melanogaster
Y54F10BM.14 C. elegans
PHF5A G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 198 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 162 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 105 21536652
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 76 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 50 21536652
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 22 18322460
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 21 27377154
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 20 24448447
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 19 18322460
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 18 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 17 20980672
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 14 17332742
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 14 19935684
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 14 24448447
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 13 11884590
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 12 11884590
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 12 16809785
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 12 16809785
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 12 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 11 27377154
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 10 27377154
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 9 11884590
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 9 18322460
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 9 23431055
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 9 24448447
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 8 23345524
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 7 11884590
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 7 20980672
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 6 18981222
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 6 11804584
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 6 16809785
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 6 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 6 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 6 19935684
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 6 23431055
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 6 27377154
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 5 20980672
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 5 16809785
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 5 19935684
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 5 23345524
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 4 19941820
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 4 11884590
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 4 19935684
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 3 19941820
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 3 19761775
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 3 24448447
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 2 18322460
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 2 20089683
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 1 21526149
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
SF3b, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, without splicing substrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae ■ 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae ■ 19935684

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