Nomenclature

Gene Symbol
SRSF6 (H. sapiens)
Other Gene Symbols
B52, FLJ08061, MGC5045, SFRS6, SRP55
Full Name
serine/arginine-rich splicing factor 6
Other Names
SRp55, SR splicing factor 6, pre-mRNA-splicing factor SRP55, serine/arginine-rich splicing factor 6, splicing factor, arginine/serine-rich, 55 kDa

Other Resources

Entrez: Gene Info
6431
Uniprot: Protein Info
SRSF6_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
112329
PDB: Structures
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SpliProt3D: Structural Model
SRSF6

Gene Product Info

Molecular Weight (kD)
39.6
Domains
RRM
Motifs
—
Features
—
Class / Family
SR protein
Notes
—

Orthologs

Name Organism
B52 D. melanogaster
W02B12.3 C. elegans
SRSF6 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SRSF6 SNRNP70 Dervied from Literature — 8139654
SRSF6 SF3B4 Y2H: Prey/Bait 0.75 22365833
SRSF6 RNPS1 Dervied from Literature — 16189514
SRSF6 SRSF4 Dervied from Literature — 16189514
SRSF6 SRPK1 Dervied from Literature — 8208298, 8798720
SRSF6 TRA2B Y2H: Prey/Bait 0.5 22365833
SRSF6 RBM10 Y2H: Prey/Bait 1 22365833
SRSF6 TOE1 Y2H: Prey/Bait 0.67 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 49 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 36 24448447
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 34 20980672
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 30 24448447
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 28 21536652
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 27 16809785
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 26 18322460
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 23 18322460
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 23 18322460
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 22 17332742
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 20 18322460
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 16 21536652
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 11 16809785
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 11 24448447
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 11 27377154
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 10 20980672
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 10 18981222
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 10 24448447
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 9 20980672
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 8 27377154
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 7 17095540
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 7 27377154
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 6 17537823
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 6 20980672
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 6 16809785
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 4 17537823
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 3 22110043
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 2 18981222
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 2 16809785
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 1 18981222
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934

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