Nomenclature

Gene Symbol
TRA2B (H. sapiens)
Other Gene Symbols
DKFZp686F18120, Htra2-beta, SFRS10, SRFS10, TRA2-BETA
Full Name
transformer 2 beta homolog (Drosophila)
Other Names
SFRS10, TRA-2 beta, splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila), transformer-2 protein homolog B, transformer-2 protein homolog beta

Other Resources

Entrez: Gene Info
6434
Uniprot: Protein Info
TRA2B_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112332
PDB: Structures
2CQC, 2KXN, 2RRA, 2RRB
SpliProt3D: Structural Model
SFRS10

Gene Product Info

Molecular Weight (kD)
33.7
Domains
RRM
Motifs
—
Features
—
Class / Family
SR protein
Notes
—

Orthologs

Name Organism
tra2 D. melanogaster
C18D11.4 C. elegans
PF10_0028 P. falciparum
TRA2B G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
TRA2B RNPS1 Dervied from Literature — 14729963
TRA2B SRSF2 Y2H: Bait/Prey 0.75 22365833
TRA2B SRSF4 Y2H: Bait/Prey 0.5 22365833
TRA2B SRSF6 Y2H: Bait/Prey 0.5 22365833
TRA2B SRSF9 Dervied from Literature — 11875052
TRA2B SRSF3 Y2H: Bait/Prey 0.5 22365833
TRA2B HNRNPA1 Y2H: Bait/Prey 0.88 22365833
TRA2B RBMX Y2H: Bait/Prey 0.75 22365833
TRA2B RBMX Dervied from Literature — 10749975, 12165565
TRA2B SRSF10 Y2H: Bait/Prey 0.56 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 50 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 37 21536652
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 35 18322460
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 34 18322460
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 33 18322460
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 32 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 29 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 29 24448447
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 24 20980672
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 21 18322460
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 17 27377154
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 16 24448447
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 16 27377154
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 13 20980672
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 12 17095540
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 12 24448447
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 9 20980672
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 8 20980672
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 8 27377154
mRNP on BetaGlobin, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 7 17095540
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 7 27377154
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 6 17095540
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 6 17537823
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 6 16809785
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 4 17537823
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 4 16809785
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 3 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 3 16809785
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 2 17332742
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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