Nomenclature

Gene Symbol
SMU1 (H. sapiens)
Other Gene Symbols
BWD, DKFZp761L0916, FLJ10805, FLJ10870, FLJ11970
Full Name
smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
Other Names
FLJ10805, WD40 repeat-containing protein SMU1, brain-enriched WD-repeat protein, functional spliceosome-associated protein 57, smu-1 suppressor of mec-8 and unc-52 protein homolog

Other Resources

Entrez: Gene Info
55234
Uniprot: Protein Info
SMU1_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
120528
PDB: Structures
—
SpliProt3D: Structural Model
SMU1

Gene Product Info

Molecular Weight (kD)
57.5
Domains
CTLH, LisH
Motifs
—
Features
—
Complex Association
B complex
Class / Family
Recruited at B complex
Notes
—

Orthologs

Name Organism
CG5451 D. melanogaster
CC4.3 C. elegans
SMU1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SMU1 LSM4 Y2H: Bait/Prey 0.4 22365833
SMU1 LSM8 Y2H: Bait/Prey 0.64 22365833
SMU1 CD2BP2 Y2H: Bait/Prey 0.4 22365833
SMU1 MFAP1 Y2H: Bidirectional 0.8 22365833
SMU1 IK Pull-down — 22365833
SMU1 IK Y2H: Bidirectional 0.98 22365833
SMU1 YBX1 Y2H: Bait/Prey 0.4 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 234 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 211 21536652
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 79 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 76 24448447
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 75 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 58 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 53 27377154
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 51 24448447
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 47 18322460
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 40 16809785
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 38 16809785
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 30 16809785
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 29 20980672
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 26 16809785
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 25 20980672
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 24 27377154
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 22 18981222
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 21 21536652
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 20 18981222
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 18 20980672
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 18 27377154
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 16 18322460
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 16 18981222
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 15 24448447
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 14 18981222
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 10 17537823
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 9 20980672
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 7 23345524
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 6 21536652
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 5 18322460
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 5 18322460
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 5 23345524
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 4 17537823
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 2 24448447
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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