Nomenclature

Gene Symbol
CWC15 (H. sapiens)
Other Gene Symbols
C11orf5, Cwf15, HSPC148, ORF5, AD-002
Full Name
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
Other Names
HSPC148, CWC15 homolog, protein CWC15 homolog

Other Resources

Entrez: Gene Info
51503
Uniprot: Protein Info
CWC15_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
119575
PDB: Structures
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SpliProt3D: Structural Model
CWC15

Gene Product Info

Molecular Weight (kD)
26.6
Domains
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Motifs
—
Features
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Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 complex
Notes
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Orthologs

Name Organism
CWC15 S. cerevisiae
cwf15 S. pombe
c12.1 D. melanogaster
T10C6.5 C. elegans
CWC15 G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 272 21386897
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 231 21536652
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 210 21386897
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 195 21386897
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 146 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 54 21536652
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 48 19935684
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 44 23431055
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 38 19941820
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 37 23431055
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 36 20980672
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 31 23431055
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 25 20980672
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 24 19935684
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 23 20980672
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 23 19935684
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 22 19941820
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 22 23431055
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 22 23431055
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 20 20980672
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 19 23431055
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 16 18322460
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 16 19941820
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 15 19935684
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 15 23431055
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 14 19935684
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 13 18981222
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 13 16809785
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 12 16809785
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 11 24448447
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 10 18322460
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 10 19941820
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 10 18322460
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 10 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 10 23345524
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 9 20089683
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 8 20089683
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 8 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 8 19935684
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 7 19761775
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 7 16809785
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 6 20089683
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 6 11991638
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 6 11884590
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 6 16809785
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 6 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 6 27377154
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 5 11884590
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 5 19935684
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 4 11884590
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 4 23431055
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 3 21386897
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 2 18322460
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 2 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
Released from Post-catalytic complex, deltaPrp22, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 1 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 1 27377154
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae ■ 19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae ■ 19935684

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