Nomenclature

Gene Symbol
ISY1 (S. cerevisiae)
Other Gene Symbols
NTC30, UTR3
Full Name
Isy1p
Other Names
ISY1, YJR050W

Other Resources

Entrez: Gene Info
853509
Uniprot: Protein Info
ISY1_YEAST
Organism-Specific Database
S000003811
BioGrid: Interaction Info
33803
PDB: Structures
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SpliProt3D: Structural Model
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Gene Product Info

Molecular Weight (kD)
28.0
Domains
—
Motifs
—
Features
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Complex Association
B complex, Bact complex, C complex, P complex
Class / Family
PRP19 related
Notes
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Orthologs

Name Organism
ISY1 H. sapiens
cwf12 S. pombe
CG9667 D. melanogaster
F53B7.3 C. elegans
ISY1 G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 331 21536652
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 272 21386897
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 269 21536652
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 259 21386897
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 141 21386897
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 61 19935684
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 54 23431055
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 40 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 39 20980672
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 37 19941820
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 31 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 29 27377154
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 28 23431055
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 27 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 25 20980672
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 24 18322460
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 24 23431055
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 23 19761775
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 23 19935684
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 23 24448447
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 22 19935684
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 22 24448447
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 19 18322460
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 18 19935684
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 18 23345524
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 17 19941820
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 17 19935684
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 16 23345524
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 16 27377154
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 15 19935684
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 14 19941820
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 14 19935684
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 14 19935684
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 14 23431055
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 13 18322460
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 13 18981222
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 13 23431055
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 12 16809785
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 12 19935684
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 12 23431055
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 11 19941820
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 11 19935684
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 10 18322460
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 10 23431055
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 9 11884590
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 9 23431055
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 9 23431055
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 8 19941820
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 8 11804584
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 8 23431055
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 8 23431055
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 7 11884590
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 7 20089683
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 7 11991638
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 7 16809785
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 6 11884590
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 6 20089683
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 6 20089683
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 6 21526149
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 6 23431055
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 5 11884590
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 5 12226669
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 5 12509417
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 5 27377154
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 4 17537823
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 4 18322460
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 4 24448447
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 4 24448447
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 4 27377154
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 3 19761775
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 3 18322460
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 3 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 3 16809785
CACN-1 pulldown with FLAG-HA tandem affinity from C. elegans, C. elegans, (Doherty et al 2014) C. elegans 3 24948787
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 2 18981222
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 2 19789211
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 2 27377154
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 1 16809785
Released from Post-catalytic complex, deltaPrp22, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 1 23431055
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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