Nomenclature

Gene Symbol
NCBP2 (H. sapiens)
Other Gene Symbols
CBC2, CBP20, NIP1, PIG55
Full Name
nuclear cap binding protein subunit 2, 20kDa
Other Names
CBP20, 20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, NCBP interacting protein 1, NCBP-interacting protein 1, cell proliferation-inducing gene 55 protein

Other Resources

Entrez: Gene Info
22916
Uniprot: Protein Info
NCBP2_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
116578
PDB: Structures
1H2T, 1H2U, 1H2V, 1H6K, 1N52
SpliProt3D: Structural Model
NCBP2

Gene Product Info

Molecular Weight (kD)
18.0
Domains
RRM
Motifs
—
Features
—
Class / Family
pre-mRNA/mRNA binding proteins
Notes
—

Orthologs

Name Organism
CBC2 S. cerevisiae
nuclear cap-binding complex small subunit S. pombe
Cbp20 D. melanogaster
F26A3.2 C. elegans
NCBP2 G. gallus
NCBP2 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
NCBP2 NCBP1 Dervied from Literature — 7478990, 9933612, 11545740, 12374755, 12434151, 12454499, 15361857
NCBP2 NCBP1 Y2H: Bidirectional 1 22365833
NCBP2 HNRNPF Dervied from Literature — 9111328
NCBP2 HNRNPH1 Dervied from Literature — 9111328

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 303 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 232 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 202 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 117 21536652
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 38 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 32 24448447
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 25 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 25 24448447
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 23 20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 22 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 19 20980672
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 19 16809785
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 16 16809785
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 16 27377154
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 15 18322460
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 15 24448447
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 14 18322460
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 12 24448447
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 12 27377154
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 11 18981222
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 11 18981222
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 9 20089683
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 8 27377154
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 7 27377154
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 6 20980672
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 6 16809785
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 5 17095540
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 5 20089683
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
mRNP unspliced control, H. sapiens, (Merz et al 2007) H. sapiens 4 17095540
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 4 20089683
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 4 16809785
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 4 22110043
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 4 27377154
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 3 17537823
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 3 27377154
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
mRNP on BetaGlobin, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 2 17537823
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 1 17332742
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
H complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
EDC complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934

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