Nomenclature

Gene Symbol
NCBP1 (H. sapiens)
Other Gene Symbols
CBP80, MGC2087, NCBP, Sto1
Full Name
nuclear cap binding protein subunit 1, 80kDa
Other Names
CBP80, 80 kDa nuclear cap-binding protein, NCBP 80 kDa subunit, nuclear cap-binding protein subunit 1

Other Resources

Entrez: Gene Info
4686
Uniprot: Protein Info
NCBP1_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
110766
PDB: Structures
1H2T, 1H2U, 1H2V, 1H6K, 1N52
SpliProt3D: Structural Model
NCBP1

Gene Product Info

Molecular Weight (kD)
91.8
Domains
MIF4G
Motifs
Nuclear localization signal
Features
—
Class / Family
pre-mRNA/mRNA binding proteins
Notes
—

Orthologs

Name Organism
STO1 S. cerevisiae
nuclear cap-binding complex large subunit (predicted) S. pombe
Cbp80 D. melanogaster
F37E3.1 C. elegans
NCBP1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
NCBP1 C17orf85 Y2H: Bait/Prey 0.5 22365833
NCBP1 NCBP2 Dervied from Literature — 7478990, 9933612, 11545740, 12374755, 12434151, 12454499, 15361857
NCBP1 NCBP2 Y2H: Bidirectional 1 22365833
NCBP1 HNRNPF Dervied from Literature — 9111328
NCBP1 HNRNPH1 Dervied from Literature — 9111328

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 209 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 149 27377154
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 111 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 110 21536652
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 108 18322460
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 103 20980672
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 99 24448447
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 98 20980672
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 95 18322460
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 90 20980672
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 87 24448447
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 78 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 76 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 74 27377154
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 69 18322460
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 65 21536652
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 62 27377154
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 61 20980672
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 48 24448447
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 47 18322460
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 46 18322460
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 45 16809785
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 41 24448447
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 37 18322460
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 37 18981222
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 35 18981222
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 34 16809785
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 33 21536652
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 32 22110043
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 25 18981222
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 25 18193060
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 24 18981222
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 24 22110043
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 21 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 21 18981222
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 16 20089683
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 13 18981222
mRNP on BetaGlobin, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 12 17095540
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 12 18193060
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 12 12226669
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 12 11991638
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 12 17537823
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 12 18193060
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 12 16809785
mRNP unspliced control, H. sapiens, (Merz et al 2007) H. sapiens 10 17095540
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 10 12226669
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 9 17095540
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 8 17095540
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 8 20089683
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 7 19941820
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 7 19761775
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 7 17332742
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 7 20089683
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 6 17095540
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 4 17095540
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 4 11991638
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 3 17537823
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 2 16809785
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
EDC complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
H complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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