Nomenclature

Gene Symbol
SYF2 (H. sapiens)
Other Gene Symbols
CBPIN, DKFZp564O2082, NTC31, P29, fSAP29
Full Name
SYF2 homolog, RNA splicing factor (S. cerevisiae)
Other Names
GCIP-IP, CCNDBP1 interactor, CCNDBP1-interactor, GCIP-interacting protein p29, functional spliceosome-associated protein 29, pre-mRNA-splicing factor SYF2

Other Resources

Entrez: Gene Info
25949
Uniprot: Protein Info
SYF2_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
117444
PDB: Structures
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SpliProt3D: Structural Model
SYF2

Gene Product Info

Molecular Weight (kD)
28.7
Domains
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Motifs
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Features
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Complex Association
C complex, P complex
Class / Family
Recruited at C complex
Notes
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Orthologs

Name Organism
SYF2 S. cerevisiae
syf2 S. pombe
CG12343 D. melanogaster
K04G7.11 C. elegans
SYF2 G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 267 21386897
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 98 21386897
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 88 21536652
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 74 20980672
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 57 21386897
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 56 23431055
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 44 19935684
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 43 19941820
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 37 19941820
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 31 20980672
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 28 18322460
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 28 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 25 19935684
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 25 24448447
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 24 23431055
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 23 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 22 19935684
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 22 23431055
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 21 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 20 24448447
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 19 19761775
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 19 19935684
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 18 18981222
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 18 19935684
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 18 23431055
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 17 23431055
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 16 18322460
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 16 19941820
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 15 23431055
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 14 19941820
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 14 20980672
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 14 18981222
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 14 23345524
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 14 23431055
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 13 11991638
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 13 19935684
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 13 23345524
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 13 23431055
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 12 19935684
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 12 23431055
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 11 20089683
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 11 20089683
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 11 20089683
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 11 19941820
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 11 20980672
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 11 19935684
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 10 23431055
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 9 21536652
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 8 23431055
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 7 11884590
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 6 11884590
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 4 11884590
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 4 17537823
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 2 11804584
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 2 12509417
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 2 19789211
Prp8 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 2 19789211
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 2 24448447
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 1 11884590
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 1 21526149
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens ■ 24448447

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