Nomenclature

Gene Symbol
EIF4A3 (H. sapiens)
Other Gene Symbols
DDX48, DKFZp686O16189, KIAA0111, MGC10862, NMP265
Full Name
eukaryotic translation initiation factor 4A3
Other Names
eIF4a-like nuclear, ATP-dependent RNA helicase DDX48, ATP-dependent RNA helicase eIF4A-3, DEAD (Asp-Glu-Ala-Asp) box polypeptide 48, DEAD box protein 48, NMP 265

Other Resources

Entrez: Gene Info
9775
Uniprot: Protein Info
IF4A3_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
115119
PDB: Structures
2HXY, 2HYI, 2J0Q, 2J0S, 2J0U
SpliProt3D: Structural Model
EIF4A3

Gene Product Info

Molecular Weight (kD)
46.9
Domains
Helicase ATP-binding, Helicase C-terminal
Motifs
DEAD box, Q motif
Features
—
Complex Association
Bact complex, C complex, P complex
Class / Family
EJC/mRNP
Notes
—

Orthologs

Name Organism
FAL1 S. cerevisiae
SPAC1F5.10 S. pombe
eIF4AIII D. melanogaster
Y65B4A.6 C. elegans
F33D11.10 C. elegans
PFD1070w P. falciparum
EIF4A3 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
EIF4A3 CWC22 Y2H: Bait/Prey 0.75 22365833
EIF4A3 CWC22 Pull-down — 22365833
EIF4A3 RBM8A Dervied from Literature — 16923391
EIF4A3 ALYREF Dervied from Literature — 14730019

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 124 21536652
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 94 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 75 20980672
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 67 18322460
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 63 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 62 24448447
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 61 18322460
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 52 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 51 20980672
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 42 24448447
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 31 21536652
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 27 18322460
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 21 18981222
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 18 17537823
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 18 18322460
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 17 23345524
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 17 24448447
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 16 18322460
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 16 18981222
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 16 24448447
mRNP on BetaGlobin, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 15 17095540
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 15 17095540
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 15 17537823
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 15 21536652
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 14 19761775
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 14 23345524
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 10 17095540
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 10 11991638
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 9 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 8 12226669
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 7 17095540
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 3 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 2 19761775
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 2 21526149
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 2 21526149
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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