Nomenclature

Gene Symbol
ALYREF (H. sapiens)
Other Gene Symbols
ALY, ALY/REF, BEF, REF, THOC4
Full Name
Aly/REF export factor
Other Names
REF, THO complex 4, THO complex subunit 4, ally of AML-1 and LEF-1, bZIP enhancing factor, bZIP-enhancing factor BEF

Other Resources

Entrez: Gene Info
10189
Uniprot: Protein Info
THOC4_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
115486
PDB: Structures
3ULH
SpliProt3D: Structural Model
THOC4

Gene Product Info

Molecular Weight (kD)
26.9
Domains
RRM
Motifs
—
Features
—
Class / Family
EJC/mRNP
Notes
—

Orthologs

Name Organism
YRA1 S. cerevisiae
mlo3 S. pombe
Aly D. melanogaster
THOC4 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
ALYREF EIF4A3 Dervied from Literature — 14730019
ALYREF RBM8A Dervied from Literature — 11546873, 11707413
ALYREF DDX39B Dervied from Literature — 14667819, 15047853

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 16 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 12 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 11 27377154
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 10 27377154
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 8 17537823
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 7 20089683
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 7 20089683
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 7 19935684
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 7 27377154
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 6 20980672
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 6 17537823
mRNP on BetaGlobin, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 5 17095540
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 5 17095540
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 5 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 5 24448447
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 5 27377154
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 4 18322460
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 4 18322460
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 4 20980672
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 3 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 3 24448447
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
mRNP unspliced control, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 2 18981222
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 2 20980672
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 2 24448447
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 1 18981222
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934

©2011 Spliceosome Component Database  All Rights Reserved.
design by juricalab