Nomenclature

Gene Symbol
PRPF4 (H. sapiens)
Other Gene Symbols
HPRP4, HPRP4P, PRP4, Prp4p
Full Name
PRP4 pre-mRNA processing factor 4 homolog (yeast)
Other Names
HPRP4, PRP4 homolog, PRP4/STK/WD splicing factor, U4/U6 small nuclear ribonucleoprotein Prp4, U4/U6 snRNP 60 kDa protein, WD splicing factor Prp4

Other Resources

Entrez: Gene Info
9128
Uniprot: Protein Info
PRP4_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
114576
PDB: Structures
1MZW
SpliProt3D: Structural Model
PRPF4

Gene Product Info

Molecular Weight (kD)
58.4
Domains
—
Motifs
—
Features
—
Complex Association
B complex, tri-snRNP, U4/U6 snRNP
Class / Family
U4/U6 snRNP
Notes
—

Orthologs

Name Organism
PRP4 S. cerevisiae
SPAC227.12 S. pombe
U4-U6-60K D. melanogaster
C36B1.5 C. elegans
PRPF4 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PRPF4 U2AF1 Y2H: Bidirectional 0.83 22365833
PRPF4 PPIH Dervied from Literature — 9570313, 12875835, 12907720, 16723661
PRPF4 PPIH Y2H: Prey/Bait 1 22365833
PRPF4 GPKOW Y2H: Prey/Bait 0.75 22365833
PRPF4 GPKOW Pull-down — 22365833
PRPF4 PRPF18 Dervied from Literature — 11823439
PRPF4 SRSF1 Dervied from Literature — 11418604

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 272 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 229 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 151 21536652
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 103 21536652
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 90 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 80 27377154
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 72 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 57 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 55 24448447
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 51 27377154
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 49 16809785
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 41 16809785
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 37 18322460
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 36 24448447
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 27 19941820
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 27 16809785
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 25 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 24 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 22 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 22 18981222
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 22 16809785
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 20 21536652
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 16 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 16 18981222
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 14 19941820
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 14 18322460
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 13 18981222
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 12 11804584
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 12 17537823
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 11 20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 11 20980672
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 10 18322460
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 8 20980672
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 7 17537823
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 7 21536652
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 6 12226669
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 6 19935684
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 5 12226669
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 4 21536652
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 4 22110043
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 3 20980672
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
H complex, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 2 24448447
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 1 23345524
tri-snRNP, S. cerevisiae, (Gottschalk et al 1999) S. cerevisiae ■ 10449419
tri-snRNP, S. cerevisiae, (Stevens et al 1999) S. cerevisiae ■ 11720284
tri-snRNP, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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