Nomenclature

Gene Symbol
PPIH (H. sapiens)
Other Gene Symbols
CYP-20, CYPH, MGC5016, SnuCyp-20, USA-CYP
Full Name
peptidylprolyl isomerase H (cyclophilin H)
Other Names
SNU-CYP, PPIase h, U-snRNP-associated cyclophilin SnuCyp-20, U-snRNP-associated cyclophilin SunCyp-20, USA-CyP SnuCyp-20, cyclophilin H

Other Resources

Entrez: Gene Info
10465
Uniprot: Protein Info
PPIH_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
115728
PDB: Structures
1MZW, 1QOI
SpliProt3D: Structural Model
PPIH

Gene Product Info

Molecular Weight (kD)
19.2
Domains
PPIase cyclophilin-type
Motifs
—
Features
—
Complex Association
B complex, tri-snRNP, U4/U6 snRNP
Class / Family
U4/U6 snRNP
Notes
—

Orthologs

Name Organism
cyp3 S. pombe
cps3 S. pombe
zf-CCCH type zinc finger protein S. pombe
CG17266 D. melanogaster
T01B7.4 C. elegans
PF08_0121 P. falciparum
PPIH G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PPIH PRPF4 Y2H: Bait/Prey 1 22365833
PPIH PRPF4 Dervied from Literature — 9570313, 12875835, 12907720, 16723661
PPIH PRPF18 Dervied from Literature — 11823439
PPIH BAG2 Y2H: Prey/Bait 0.5 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 99 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 88 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 68 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 57 27377154
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 46 16809785
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 27 24448447
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 27 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 26 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 24 18322460
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 23 27377154
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 22 16809785
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 17 21536652
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 17 27377154
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 16 24448447
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 15 16809785
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 14 18322460
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 12 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 10 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 10 18981222
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 6 20980672
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 6 21536652
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 5 12226669
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 4 20980672
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 4 22110043
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 3 16809785
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 2 17537823
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 2 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 1 20980672
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 1 23345524
tri-snRNP, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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