Nomenclature

Gene Symbol
HSH49 (S. cerevisiae)
Other Gene Symbols
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Full Name
Hsh49p
Other Names
HSH49, YOR319W

Other Resources

Entrez: Gene Info
854497
Uniprot: Protein Info
HSH49_YEAST
Organism-Specific Database
S000005846
BioGrid: Interaction Info
34705
PDB: Structures
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SpliProt3D: Structural Model
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Gene Product Info

Molecular Weight (kD)
24.5
Domains
RRM
Motifs
—
Features
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Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex
Class / Family
17S U2 snRNP
Notes
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Orthologs

Name Organism
SF3B4 H. sapiens
sap49 S. pombe
Spx D. melanogaster
CELE_C08B11.5 C. elegans
SF3B4 G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 173 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 173 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 158 21536652
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 112 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 52 21536652
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 43 27377154
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 43 27377154
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 41 19941820
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 26 19935684
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 21 19935684
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 20 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 17 19935684
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 16 27377154
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 14 19935684
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 13 16809785
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 13 23431055
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 12 27377154
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 11 19935684
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 10 20980672
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 10 16809785
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 10 19935684
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 9 11804584
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 9 20980672
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 9 16809785
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 9 16809785
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 8 19935684
SRM160 pulldown with BIC8 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 8 16159877
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 8 23431055
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 7 17332742
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 7 23431055
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 6 19941820
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 6 24448447
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 5 23431055
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 4 19941820
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 4 20089683
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 4 20980672
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 4 23431055
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 3 20980672
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 3 17537823
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 3 19935684
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 3 23345524
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 3 22110043
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 3 23431055
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 2 18981222
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 2 23345524
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
SRM160 pulldown with Srm160 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 2 16159877
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 2 24448447
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 1 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 1 21526149
SRM300 pulldown with Srm300 antibody, H. sapiens, (McCracken et al 2005) H. sapiens 1 16159877
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
SF3b, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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