Nomenclature

Gene Symbol
CWC22 (S. cerevisiae)
Other Gene Symbols
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Full Name
Cwc22p
Other Names
CWC22, YGR278W

Other Resources

Entrez: Gene Info
853195
Uniprot: Protein Info
CWC22_YEAST
Organism-Specific Database
S000003510
BioGrid: Interaction Info
33528
PDB: Structures
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SpliProt3D: Structural Model
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Gene Product Info

Molecular Weight (kD)
67.3
Domains
MI, MIF4G
Motifs
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Features
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Complex Association
Bact complex, C complex, P complex
Class / Family
Recruited at Bact complex
Notes
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Orthologs

Name Organism
CWC22 H. sapiens
cwf22 S. pombe
ncm D. melanogaster
F33A8.1 C. elegans
CWC22 G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 191 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 159 20980672
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 159 21386897
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 158 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 150 20980672
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 133 23431055
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 132 19935684
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 106 23431055
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 97 23431055
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 74 21386897
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 68 18322460
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 67 18322460
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 67 19941820
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 56 19935684
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 56 19935684
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 55 18322460
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 55 23431055
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 53 24448447
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 50 24448447
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 48 19941820
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 48 21536652
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 46 19935684
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 42 18322460
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 41 19935684
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 41 21536652
Released with ILS, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 40 23431055
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 39 19935684
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 33 19941820
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 31 23431055
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 28 23431055
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 27 19935684
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 26 23345524
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 25 23345524
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 24 19761775
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 22 19935684
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 21 20089683
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 21 27377154
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 20 24448447
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 17 19941820
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 16 11991638
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 15 19935684
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 12 20089683
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 11 18322460
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 10 20089683
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 10 19761775
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 10 27377154
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 9 11884590
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 9 12226669
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 9 21536652
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 9 23431055
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 8 24448447
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 7 17537823
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 7 23431055
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 6 11884590
Released from Post-catalytic complex, deltaPrp22, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 6 23431055
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 4 19935684
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 4 23431055
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 3 21526149
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 3 21526149
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 3 27377154
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 2 23431055
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 1 27377154
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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