Nomenclature

Gene Symbol
U2AF1 (H. sapiens)
Other Gene Symbols
DKFZp313J1712, FP793, RN, RNU2AF1, U2AF35
Full Name
U2 small nuclear RNA auxiliary factor 1
Other Names
U2AF35, U2 small nuclear RNA auxillary factor 1, U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit, U2 snRNP auxiliary factor small subunit, U2(RNU2) small nuclear RNA auxiliary factor binding protein, splicing factor U2AF 35 kDa subunit

Other Resources

Entrez: Gene Info
7307
Uniprot: Protein Info
U2AF1_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
113157
PDB: Structures
1JMT
SpliProt3D: Structural Model
U2AF1

Gene Product Info

Molecular Weight (kD)
27.9
Domains
RRM
Motifs
—
Features
—
Complex Association
A complex
Class / Family
17S U2 snRNP associated
Notes
—

Orthologs

Name Organism
U2AF small subunit, U2AF-23 S. pombe
U2af38 D. melanogaster
Y116A8C.35 C. elegans
PF11_0200 P. falciparum
U2AF1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
U2AF1 SNRPD1 Y2H: Prey/Bait 0.67 22365833
U2AF1 SF3B1 Dervied from Literature — 9671485
U2AF1 SF3B2 Y2H: Bait/Prey 0.5 22365833
U2AF1 SF3B2 Pull-down — 22365833
U2AF1 U2AF2 Dervied from Literature — 1388271, 8647433, 9528748, 11551507, 16189514
U2AF1 U2AF2 Y2H: Bidirectional 1 22365833
U2AF1 SMNDC1 Dervied from Literature — 18211889
U2AF1 CHERP Y2H: Bidirectional 1 22365833
U2AF1 PRPF40A Y2H: Prey/Bait 0.81 22365833
U2AF1 PRPF4 Y2H: Bidirectional 0.83 22365833
U2AF1 PRPF19 Y2H: Prey/Bait 0.75 22365833
U2AF1 MFAP1 Y2H: Prey/Bait 0.5 22365833
U2AF1 PRPF38A Y2H: Prey/Bait 1 22365833
U2AF1 DHX38 Y2H: Prey/Bait 0.85 22365833
U2AF1 RNPS1 Y2H: Prey/Bait 1 22365833
U2AF1 SRSF1 Dervied from Literature — 8261509, 8816452, 9799243
U2AF1 SRSF2 Dervied from Literature — 8261509, 8816452
U2AF1 SRSF2 Y2H: Prey/Bait 1 22365833
U2AF1 SRPK1 Dervied from Literature — 9472028
U2AF1 SRPK1 Y2H: Bidirectional 1 22365833
U2AF1 NKAP Y2H: Prey/Bait 0.89 22365833
U2AF1 NKAP Pull-down — 22365833
U2AF1 RBM10 Y2H: Prey/Bait 1 22365833
U2AF1 PABPC1 Y2H: Prey/Bait 0.52 22365833
U2AF1 TOE1 Y2H: Prey/Bait 0.67 22365833
U2AF1 ZCCHC10 Y2H: Prey/Bait 1 22365833
U2AF1 FRA10AC1 Y2H: Bidirectional 0.94 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 56 21536652
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 26 16809785
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 18 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 7 16809785
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 7 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 7 27377154
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 6 18193060
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 6 27377154
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 4 22110043
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 3 17537823
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 2 17537823
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 2 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 2 16809785
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 1 17332742
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens ■ 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens ■ 24448447
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

©2011 Spliceosome Component Database  All Rights Reserved.
design by juricalab