Nomenclature

Gene Symbol
PABPC1 (H. sapiens)
Other Gene Symbols
PAB1, PABP, PABP1, PABPC2, PABPL1
Full Name
poly(A) binding protein, cytoplasmic 1
Other Names
PAB1 , poly(A) binding protein, cytoplasmic 2, polyadenylate-binding protein 1

Other Resources

Entrez: Gene Info
26986
Uniprot: Protein Info
PABP1_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
117939
PDB: Structures
1CVJ, 1G9L, 1JGN, 1JH4, 2K8G
SpliProt3D: Structural Model
PABPC1

Gene Product Info

Molecular Weight (kD)
70.7
Domains
PABC, RRM
Motifs
—
Features
—
Class / Family
pre-mRNA/mRNA binding proteins
Notes
—

Orthologs

Name Organism
PAB1 S. cerevisiae
pabp S. pombe
PFL1170w P. falciparum
PABPC1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
PABPC1 U2AF1 Y2H: Bait/Prey 0.52 22365833
PABPC1 GNB2L1 Dervied from Literature — 12388589
PABPC1 PABPC1 Dervied from Literature — 10499800
PABPC1 HNRNPD Dervied from Literature — 16556936, 16902409
PABPC1 HNRNPK Y2H: Bait/Prey 0.4 22365833
PABPC1 RBM4 Y2H: Bait/Prey 0.4 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 89 19935684
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 40 27377154
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 35 19935684
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 33 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 29 18322460
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 22 27377154
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 20 27377154
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 18 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 16 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 15 24448447
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 14 23345524
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 10 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 9 21536652
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 9 24448447
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 8 20980672
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 8 24448447
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 7 20980672
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 7 23345524
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 5 18322460
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 5 20980672
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 5 20980672
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529

©2011 Spliceosome Component Database  All Rights Reserved.
design by juricalab