Nomenclature

Gene Symbol
SRSF1 (H. sapiens)
Other Gene Symbols
ASF, FLJ53078, MGC5228, SF2, SF2p33
Full Name
serine/arginine-rich splicing factor 1
Other Names
ASF/SF2, ASF-1, SR splicing factor 1, alternative-splicing factor 1, pre-mRNA-splicing factor SF2, P33 subunit, serine/arginine-rich splicing factor 1

Other Resources

Entrez: Gene Info
6426
Uniprot: Protein Info
SRSF1_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112324
PDB: Structures
1X4A, 2O3D, 3BEG
SpliProt3D: Structural Model
SRSF1

Gene Product Info

Molecular Weight (kD)
27.7
Domains
RRM
Motifs
—
Features
—
Class / Family
SR protein
Notes
—

Orthologs

Name Organism
SF2 D. melanogaster
Y111B2A.18 C. elegans
SRSF1 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SRSF1 SNRNP70 Dervied from Literature — 8139654, 9685421, 9799243
SRSF1 U2AF1 Dervied from Literature — 8261509, 8816452, 9799243
SRSF1 U2AF2 Dervied from Literature — 8261509, 9582097, 16189514
SRSF1 PRPF4 Dervied from Literature — 11418604
SRSF1 RNPS1 Y2H: Bidirectional 0.55 22365833
SRSF1 SRSF1 Dervied from Literature — 8816452, 9799243
SRSF1 SRSF2 Dervied from Literature — 8816452
SRSF1 SRSF4 Y2H: Bait/Prey 0.8 22365833
SRSF1 SRSF5 Dervied from Literature — 9799243
SRSF1 SRPK1 Dervied from Literature — 8208298, 8798720, 9472028, 10196197, 10390541, 12565863, 17517895
SRSF1 HNRNPA0 Y2H: Bait/Prey 0.6 22365833
SRSF1 SRSF10 Y2H: Bait/Prey 0.8 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 253 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 207 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 107 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 100 21536652
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 89 17332742
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 77 18322460
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 68 16809785
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 55 16809785
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 42 20980672
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 42 18322460
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 37 16809785
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 32 18322460
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 32 24448447
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 29 18322460
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 29 20980672
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 29 27377154
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 28 20980672
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 28 24448447
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 28 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 27 27377154
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 24 20980672
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 24 24448447
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 24 27377154
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 21 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 18 18322460
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 18 16809785
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 18 24448447
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 15 18981222
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 15 27377154
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 12 12226669
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 11 12226669
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 10 22110043
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 9 18981222
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 7 22110043
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 6 17095540
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 6 18193060
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 5 17095540
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 4 17537823
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 4 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
mRNP on BetaGlobin, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 3 17537823
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

©2011 Spliceosome Component Database  All Rights Reserved.
design by juricalab